Fig. 2

Volcano plots and hierarchical clusters of differentially expressed lncRNAs and mRNAs. a LncRNA volcano plots of SLE patients versus normal controls. b A total of 163 lncRNAs were differentially expressed in moDCs of patients with SLE (n = 5) compared with normal controls (n = 5), including 118 upregulated and 45 downregulated lncRNA (fold change (FC) ≥ 2.0, P < 0.05). c mRNA volcano plots of SLE patients versus normal controls. d A total of 137 mRNAs were differentially expressed in moDCs of patients with SLE (n = 5) compared with normal controls (n = 5), including 83 upregulated and 54 downregulated mRNAs (fold change ≥ 2.0, P < 0.05). In a and c, each point represents a different transcript. Red points represent genes that were significantly upregulated and green points represent genes that were significantly downregulated. In b and d, relatively high expression is indicated by red shading and relatively low expression is indicated by green shading. N1–5 represents normal controls and S1–5 represents the patients with SLE