| All patients | ADA-positive patients | ADA-negative patients | |||
---|---|---|---|---|---|---|
 | PF-06438179/GP1111 | Infliximab-EU | PF-06438179/GP1111 | Infliximab-EU | PF-06438179/GP1111 | Infliximab-EU |
Ctrough, median (5th–95th percentile), ng/ml | ||||||
 Week 0 (day 1) | n = 322 0 (0–0) | n = 323 0 (0–0) | n = 156 0 (0–0) | n = 166 0 (0–0) | n = 163 0 (0–0) | n = 156 0 (0–0) |
 Week 2 | n = 316 16,830 (6241–28,660) | n = 323 16,070 (6241–27,270) | n = 155 15,540 (5675–26,780) | n = 166 14,230 (5243–26,130) | n = 161 18,230 (6316–28,830) | n = 157 18,020 (9075–29,630) |
 Week 4 | n = 308 23,540 (4300–45,750) | n = 314 21,250 (2258–40,120) | n = 151 17,760 (765–37,420) | n = 164 16,370 (256–32,450) | n = 157 27,850 (10,660–49,180) | n = 150 26,880 (12,980–41,390) |
 Week 6 | n = 308 10,020 (102–26,650) | n = 315 9266 (0–24,180) | n = 151 6159 (0–20,180) | n = 163 5122 (0–17,440) | n = 157 14,030 (3960–29,890) | n = 152 12,790 (4321–26,420) |
 Week 14 | n = 302 1497 (0–10,590) | n = 310 1025 (0–7643) | n = 154 0 (0–4014) | n = 159 0 (0–3428) | n = 148 3351 (492–15,660) | n = 151 3063 (197–8440) |
 Week 22 | n = 295 576 (0–7911) | n = 303 433 (0–6221) | n = 152 0 (0–2262) | n = 156 0 (0–1151) | n = 143 2977 (206–10,640) | n = 147 2489 (0–7577) |
 Week 30 | n = 281 413 (0–7253) | n = 290 279 (0–6017) | n = 143 0 (0–533) | n = 149 0 (0–575) | n = 138 2846 (386–10,050) | n = 141 2385 (192–7580) |
Cmax, median (5th–95th percentile), ng/ml | ||||||
 Week 0 (day 1) | n = 319 64,240 (31,570–102,000) | n = 322 62,200 (23,260–95,990) | n = 154 63,830 (35,630–101,500) | n = 166 59,290 (1603–93,170) | n = 162 65,530 (11,180–102,000) | n = 155 66,080 (29,140–101,200) |
 Week 14 | n = 297 71,250 (1617–150,500) | n = 299 68,450 (3367–144,500) | n = 149 68,280 (0–157,500) | n = 152 62,010 (1091–118,200) | n = 148 75,640 (5633–129,400) | n = 147 75,090 (8857–159,800) |