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Table 5 Exploratory analysis of the relationships between overall work impairment outcomes and type of drug received

From: Effect of subcutaneous tocilizumab treatment on work/housework status in biologic-naïve rheumatoid arthritis patients using inverse probability of treatment weighting: FIRST ACT-SC study

  TCZ-SC group csDMARDs-alone group
Work impairment measures n Standardized regression coefficient 95% CI P value n Standardized regression coefficient 95% CI P value
Presenteeism (%) 143 −0.5751 −0.7214, −0.4289 <  0.0001 147 −0.6999 −0.8240, −0.5758 < 0.0001
Overall work impairment (%) 143 −0.5950 −0.7393, −0.4507 <  0.0001 147 −0.6845 −0.8094, −0.5595 < 0.0001
Activity impairment (%) 143 −0.4754 −0.6287, −0.3221 <  0.0001 147 −0.5008 −0.6562, −0.3453 < 0.0001
HAQ-DI 143 −0.4107 −0.5707, −0.2508 <  0.0001 147 −0.1920 −0.3696, −0.0145 0.0343
EQ-5D 143 0.2840 0.1164, 0.4516 0.0011 147 0.2872 0.1126, 0.4618 0.0014
DAS28-ESR 143 −0.2961 −0.4581, −0.1342 0.0004 147 −0.2434 −0.4140, −0.0729 0.0055
CDAI 143 −0.1629 −0.3320, 0.0061 0.0587 147 −0.1608 −0.3287, 0.0070 0.0602
SDAI 143 −0.2030 −0.3709, −0.0351 0.0182 147 −0.1639 −0.3321, 0.0043 0.0560
WFun 143 −0.3748 −0.5403, −0.2092 <  0.0001 147 −0.1875 −0.3544, −0.0206 0.0280
K6 143 −0.1408 −0.3142, 0.0327 0.1108 147 −0.2002 −0.3704, − 0.0300 0.0215
  1. Adjusted for sex, age, disease duration, job type, use of methotrexate, Steinbrocker stage, and Steinbrocker class
  2. CDAI clinical disease activity index, CI confidence interval, csDMARD conventional synthetic disease-modifying antirheumatic drug, DAS28-ESR disease activity score in 28 joints using the erythrocyte sedimentation rate, EQ-5D EuroQol 5 dimension, HAQ-DI health assessment questionnaire disability index, K6 6-item Kessler psychological distress scale, SDAI simplified disease activity index, TCZ-SC tocilizumab by subcutaneous injection, WFun work functioning impairment scale