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Table 4 Hierarchical linear model (HLM) of long-term relations of serum levels of BAFF and anti-Jo-1 antibodies with serum levels of CK, CRP, and disease activity

From: Serum levels of B-cell activating factor of the TNF family (BAFF) correlate with anti-Jo-1 autoantibodies levels and disease activity in patients with anti-Jo-1positive polymyositis and dermatomyositis

Predictors ICCa Explained variance (%)b Intercept Slopec
BAFF anti-Jo-1 CK BAFF (ng/ml) p anti- Jo-1 (kU/l) p CK (μkat/l) p BAFF (ng/ml) p anti- Jo-1 (kU/l) p CK (μkat/l) p
Time from diagnosisd,e 0 62.3 31.2 1.85 ˂ 0.001 340.9 0.04 9.06 0.04 0.01 0.10 11.9 0.21 −0.06 0.63
BAFFe (ng/ml) 0.030 79.1 49.6 748.0 0.03 0 0.99 91.6 0.22 4.34 0.003
anti-Jo-1e (kU/l) 0.678 31.6 72.3 2.33 ˂ 0.001 1.4 0.34 0.002 0.03 0.02 0.05
CKe (μkat/l) 0.100 75.6 73.8 2.30 ˂ 0.001 747.1 0.03 0.14 0.02 7.14 0.59
CRPf (mg/l) 0.107 74.3 70.2 44.1 2.35 ˂ 0.001 749.5 0.03 8.7 0.02 0.15 0.08 − 21.7 0.76 0.98 0.07
Pulmonary VASg (mm) 0.582 61.7 60.4 ND 2.32 ˂ 0.001 785.8 0.03 ND 0.11 0.16 −16.5 0.03 ND
Muscle VASg (mm) 0.319 84.5 71.9 ND 2.32 ˂ 0.001 784.4 0.03 ND −0.12 0.54 −7.8 0.22 ND
Global VASg (mm) 0.241 28.3 71.2 ND 1.30 ˂ 0.001 939.3 0.07 ND 0.06 0.01 −7.4 0.21 ND
  1. Dependent variables are situated in columns and predictors in rows
  2. BAFF B-cell activating factor of the tumour necrosis factor family, CK creatine kinase, CRP C-reactive protein, ICC intra-class correlation coefficient, ND not done, VAS visual analogue scale
  3. aICC; the ratio of the between-individuals variance (level 2) to the total variance
  4. b% of variance explained at level 1 (within individuals): pseudo R2; based on HLM
  5. cAverage effect of explanatory variables (Slope) was estimated using maximum likelihood method with robust standard errors
  6. dAverage change over time (months from diagnosis); based on the unconditional growth model
  7. eDetermined in 80 repeated measures on 23 patients
  8. fDetermined in 79 repeated measures on 23 patients
  9. gDetermined in 73 repeated measures on 22 patients