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Table 2 Changes of the inflammatory and structural parameters between baseline and week 24

From: Resolution of synovitis and arrest of catabolic and anabolic bone changes in patients with psoriatic arthritis by IL-17A blockade with secukinumab: results from the prospective PSARTROS study

Characteristic

Baseline

Week 24

P value

MRI

 PSAMRIS Synovitis (median,IQR)

3 (2, 7)

2 (0, 4)

0.034*

 PSAMRIS Osteitis (median,IQR), (mean ± SD)†

0 (0, 5)†, 1.2 ± 3.1

0 (0, 0)†, 0.5 ± 1.3

0.180

 PSAMRIS Periarticular (median,IQR) (mean ± SD)†

0 (0, 1)†, 0.7 ± 1.6

0 (0, 0)†, 0 ± 0

0.059

 PSAMRIS Tenossynovitis (median,IQR) (mean ± SD)†

0 (0, 1.5)†, 1.2 ± 2.2

0 (0, 0)†, 0.7 ± 1.7

0.400

 PSAMRIS Erosions (median, IQR)

1 (0, 3)

1 (0, 4)

0.167

 PSAMRIS Proliferation (median,IQR) (mean ± SD)†

0 (0, 1)†, 1.2 ± 2.6

0 (0, 1)†, 1.2 ± 2.6

0.655

 Total PSAMRIS (median, IQR)

6 (3.5, 18)

4 (1, 13.5)

0.039*

PDUS

 OMERACT Hypertrophy (median, IQR)

5 (2, 9.5)

1 (0, 3.5)

0.009**

 OMERACT Effusion (median, IQR) (mean ± SD)†

4 (0.5, 6.5)†, 4.1 ± 3.9

0 (0, 4)†, 2.3 ± 3.2

0.084

 OMERACT Power Doppler (median, IQR) (mean ± SD)†

2 (0.5, 5.5)†, 3.6 ± 4.1

0 (0, 3)†, 1.8 ± 2.7

0.030**

 Global OMERACT (median, IQR)

5 (3, 11)

1 (0, 5)

0.003**

HR-pQCT

 Erosion Number (median, IQR)

2 (0.5, 4.5)

2 (1, 4)

0.059

 Erosion Volume (median, IQR)

3.29 (0.40, 14.68)

3.87 (0.41, 16.7)

0.859

 Proliferation Grade (median, IQR)

2 (1,2)

2 (1.5, 2)

0.083

  1. HR-pQCT high-resolution peripheral quantitative computed tomography, IQR interquartile range, MRI magnetic resonance imaging, OMERACT outcome measures in rheumatoid arthritis clinical trials, PDUS power Doppler ultrasound, PSAMRIS psoriatic arthritis magnetic resonance imaging scoring system. †Additionally reported as mean and standard deviation (mean ± standard deviation) because median was equal to zero. Data are based on 17 psoriatic arthritis patients with complete baseline and 24 week data. Wilcoxon signed-rank test. *P ≤0.05, **P ≤0.01