Skip to main content

Table 4 Association between sociodemographic/clinical characteristicsa at the index date and occurrence of knee replacement

From: Impact of oral osteoarthritis therapy usage among other risk factors on knee replacement: a nested case-control study using the Osteoarthritis Initiative cohort

  Crude OR 95% CI p b
Race: white or Caucasian (reference other race) 1.84 (1.13–2.99) 0.015
Education level: college graduate or above (reference less than college graduate) 0.95 (0.65–1.38) 0.778
BMI ≥ 27 kg/m2 (reference < 27 kg/m2) 1.65 (1.06–2.58) 0.027
WOMAC
 Function 1.04 (1.02–1.06) < 0.001
 Stiffness 1.25 (1.12–1.40) 0.001
 Total 1.03 (1.02–1.04) < 0.001
KOOS
 Pain 0.98 (0.97–0.99) < 0.001
 Symptoms 0.98 (0.97–0.99) < 0.001
 QoL 0.97 (0.96–0.98) < 0.001
X-ray (JSW) 0.93 (0.85–1.01) 0.092
MRI
 BML
  By increase of 1% 1.04 (0.99–1.09) 0.144
  BML ≥ 1% (reference < 1%) 1.41 (0.95–2.11) 0.091
  Meniscal extrusion (reference no extrusion) 1.18 (0.80–1.73) 0.404
  1. BMI body mass index, BML bone marrow lesion, CI confidence interval, JSW joint space width, KOOS Knee injury and Osteoarthritis Outcome Score, OR odds ratio, QoL quality of life, WOMAC Western Ontario and McMaster Universities Osteoarthritis Index
  2. aExcluding characteristics used in the matching between cases and controls (i.e. age, gender, income, WOMAC pain, and KL grade)
  3. bCrude conditional logistic regression. Bold indicates statistical significance (p < 0.05)