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Table 4 Association between sociodemographic/clinical characteristicsa at the index date and occurrence of knee replacement

From: Impact of oral osteoarthritis therapy usage among other risk factors on knee replacement: a nested case-control study using the Osteoarthritis Initiative cohort

 

Crude OR

95% CI

p b

Race: white or Caucasian (reference other race)

1.84

(1.13–2.99)

0.015

Education level: college graduate or above (reference less than college graduate)

0.95

(0.65–1.38)

0.778

BMI ≥ 27 kg/m2 (reference < 27 kg/m2)

1.65

(1.06–2.58)

0.027

WOMAC

 Function

1.04

(1.02–1.06)

< 0.001

 Stiffness

1.25

(1.12–1.40)

0.001

 Total

1.03

(1.02–1.04)

< 0.001

KOOS

 Pain

0.98

(0.97–0.99)

< 0.001

 Symptoms

0.98

(0.97–0.99)

< 0.001

 QoL

0.97

(0.96–0.98)

< 0.001

X-ray (JSW)

0.93

(0.85–1.01)

0.092

MRI

 BML

  By increase of 1%

1.04

(0.99–1.09)

0.144

  BML ≥ 1% (reference < 1%)

1.41

(0.95–2.11)

0.091

  Meniscal extrusion (reference no extrusion)

1.18

(0.80–1.73)

0.404

  1. BMI body mass index, BML bone marrow lesion, CI confidence interval, JSW joint space width, KOOS Knee injury and Osteoarthritis Outcome Score, OR odds ratio, QoL quality of life, WOMAC Western Ontario and McMaster Universities Osteoarthritis Index
  2. aExcluding characteristics used in the matching between cases and controls (i.e. age, gender, income, WOMAC pain, and KL grade)
  3. bCrude conditional logistic regression. Bold indicates statistical significance (p < 0.05)