Acetaminophen | NSAIDs | COX-2 inhibitors | Narcotics | Glucosamine/chondroitin sulfate | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | ORb | 95% CI | p c | n | ORb | 95% CI | p c | n | ORb | 95% CI | p c | n | ORb | 95% CI | p c | n | ORb | 95% CI | p c | |
Primary analysis | ||||||||||||||||||||
In the 3 years prior to index date (n = 521: 161 KR/360 controls) | ||||||||||||||||||||
Exposure 1–79%a | 124 | 1.09 | (0.66–1.78) | 0.745 | 313 | 1.05 | (0.64–1.72) | 0.839 | 68 | 1.13 | (0.48–2.67) | 0.784 | 67 | 1.00 | (0.48–2.09) | 0.995 | 120 | 0.85 | (0.50–1.48) | 0.573 |
Exposure ≥ 80%a | 14 | 1.11 | (0.30–4.09) | 0.872 | 44 | 1.66 | (0.93–2.95) | 0.086 | 21 | 1.15 | (0.47–2.83) | 0.761 | ND | 163 | 0.73 | (0.43–1.23) | 0.236 | |||
Secondary Analyses | ||||||||||||||||||||
In the 2 years prior to index date (n = 642: 193 KR/449 controls) | ||||||||||||||||||||
Exposure 1–79%a | 210 | 1.10 | (0.66–1.84) | 0.722 | 369 | 0.96 | (0.60–1.54) | 0.853 | 88 | 1.40 | (0.57–3.48) | 0.465 | 77 | 1.19 | (0.54–2.58) | 0.670 | 255 | 0.70 | (0.39–1.26) | 0.235 |
Exposure ≥ 80%a | 20 | 1.46 | (0.69–3.11) | 0.322 | 58 | 1.41 | (0.88–2.26) | 0.159 | 27 | 1.18 | (0.55–2.52) | 0.671 | ND | 166 | 1.00 | (0.65–1.55) | 0.989 | |||
In the 4 years prior to index date (n = 363: 121 KR/242 controls) | ||||||||||||||||||||
Exposure 1–79%a | 113 | 1.34 | (0.74–2.41) | 0.333 | 234 | 1.40 | (0.78–2.52) | 0.256 | 50 | 1.63 | (0.64–4.13) | 0.303 | 50 | 1.43 | (0.62–3.33) | 0.405 | 156 | 0.65 | (0.33–1.25) | 0.191 |
Exposure ≥ 80%a | ND | 26 | 1.65 | (0.75–3.66) | 0.215 | ND | ND | 83 | 0.63 | (0.32–1.21) | 0.165 | |||||||||
In the 5 years prior to index date (n = 228: 82 KR/146 controls) | ||||||||||||||||||||
Exposure 1–79%a | 60 | 1.38 | (0.66–2.88) | 0.397 | 110 | 1.88 | (0.85–4.20) | 0.121 | 18 | 1.35 | (0.41–4.49) | 0.623 | 33 | 1.19 | (0.48–2.93) | 0.706 | 54 | 0.90 | (0.37–2.14) | 0.803 |
Exposure ≥ 80%a | 15 | 1.66 | (0.44–6.35) | 0.457 | 45 | 2.27 | (0.90–5.71) | 0.081 | ND | ND | 70 | 0.73 | (0.33–1.64) | 0.445 |