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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: ADAM-17 is expressed on rheumatoid arthritis fibroblast-like synoviocytes and regulates proinflammatory mediator expression and monocyte adhesion

Fig. 2

Expression of ADAM-17 in RA STs and FLSs. a Representative photomicrographs of synovial tissues (STs) from patient with RA. The left panel shows ST staining with rabbit anti-ADAM-17. The middle panel shows staining with mouse anti-collagen-1. The right panel shows merging of the left panel and middle panel. The yellow color indicates ADAM-17 associated with ST synovium. b Representative photomicrographs of ST samples from patient with OA. c and d Representative photomicrographs of RA fibroblast-like synoviocytes (FLSs). Cryosections and culture cells were stained for ADAM-17 (c) or control IgG (d). (Original magnification ×200 (a and b) ×400 (c and d)) e ADAM-17 mRNA in TNF-α stimulated RA FLSs is increased 2.4-fold compared with nonstimulated RA FLSs. ADAM a disintegrin and metalloprotease family, FLSs fibroblast-like synoviocytes, OA osteoarthritis, RA rheumatoid arthritis

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Arthritis Research & Therapy

ISSN: 1478-6362

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