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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance

Fig. 2

MCC22 is ~ 3000-fold more potent than morphine. a Mechanical thresholds were measured at the indicated times after administration of MCC22 (8 μmol/kg) or morphine (13.25 μmol/kg) to arthritic K/B.g7 mice; n = 4–10 mice/group, bars represent means ± SD. b Arthritic K/B.g7 mice received injections of vehicle, MCC22, MCC14, or morphine intraperitoneally at the indicated doses. The mechanical pain threshold was determined 2 hours later for vehicle, MCC22, MCC14, and 30 min later for morphine. Each bar includes data from 5 to 12 mice. The data were compared within each group using either paired t tests (for vehicle and MCC14) or one-way ANOVA followed by post-hoc Tukey’s test (for MCC22 and morphine). Data are presented as mean ± SEM; *p < 0.05, ***p < 0.001, versus the baseline for the group. c The mean data are displayed as a percent change from baseline. d The calculated ED50 of each compound is shown, along with the 95% confidence interval (CI)

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