Table 1 Demographic and clinical characteristics of all new episodes* of allopurinol or febuxostat use
| Â | All episodes | Incident dementia* during the follow-up | P value | |
|---|---|---|---|---|
Yes | No | |||
Total, N (episodes) | 42,704 | 2591 | 40,113 | Â |
Age in years, mean (SD) | 76.0 (7.38) | 80.8 (7.36) | 75.7 (7.27) | < 0.0001 |
Sex, N (%) |  |  |  | < 0.0001 |
 Male | 22,125 (51.8%) | 1099 (42.4%) | 21,026 (52.4%) |  |
 Female | 20,579 (48.2%) | 1492 (57.6%) | 19,087 (47.6%) | |
Race/Ethnicity, N (%) |  |  |  | < 0.0001 |
 White | 33,409 (78.2%) | 1975 (76.2%) | 31,434 (78.4%) |  |
 Black | 5317 (12.5%) | 391 (15.1%) | 4926 (12.3%) | |
 Hispanic | 898 (2.1%) | 65 (2.5%) | 833 (2.1%) | |
 Asian | 2073 (4.9%) | 118 (4.6%) | 1955 (4.9%) | |
 Native American | 129 (0.3%) | 10 (0.4%) | 119 (0.3%) | |
 Other/unknown | 878 (1.3%) | 32 (1.2%) | 846 (2.1%) | |
Region, N (%) |  |  |  | < 0.0001 |
 Midwest | 10,488 (24.6%) | 582 (22.5%) | 9906 (24.7%) |  |
 Northeast | 6901 (16.2%) | 526 (20.3%) | 6375 (15.9%) | |
 South | 17,351 (40.6%) | 1081 (41.7%) | 16,270 (40.6%) | |
 West | 7964 (18.6%) | 402 (15.5%) | 7562 (18.9%) | |
Charlson-Romano comorbidity score, mean (SD) | 1.77 (2.09) | 2.31 (2.26) | 1.74 (2.08) | < 0.0001 |