TY - JOUR AU - Marchetti, Carlo AU - Swartzwelter, Benjamin AU - Koenders, Marije I. AU - Azam, Tania AU - Tengesdal, Isak W. AU - Powers, Nick AU - de Graaf, Dennis M. AU - Dinarello, Charles A. AU - Joosten, Leo A. B. PY - 2018 DA - 2018/08/03 TI - NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis JO - Arthritis Research & Therapy SP - 169 VL - 20 IS - 1 AB - Activation of the NLRP3 inflammasome in gout amplifies the inflammatory response and mediates further damage. In the current study, we assessed the therapeutic effect of OLT1177, an orally active NLRP3 inflammasome inhibitor that is safe in humans, in murine acute arthritis models. SN - 1478-6362 UR - https://doi.org/10.1186/s13075-018-1664-2 DO - 10.1186/s13075-018-1664-2 ID - Marchetti2018 ER -