Fig. 1

Effect of OLT1177 on zymosan-induced arthritis. a Representative images of knees from saline injected (Saline), vehicle-treated, and OLT1177 (200 mg/kg)-treated mice. b Mean ± SEM of joint score (n = 16 per group). c and d H&E-stained histological knee sections from vehicle- and OLT1177-treated mice. Original magnification 100 ×. e Mean ± SEM of cell influx (n = 5 per group). f–i Mean ± SEM percent change of interleukin (IL)-1β (range 189–2488 pg/ml), IL-6 (range 100–843 pg/ml), chemokine (C-X-C motif) ligand 1 (CXCL1) (range 169–472 pg/ml), and tumor necrosis factor (TNF)-α (282–405 pg/ml) in synovial tissue extracts from mice subjected to experimental zymosan-induced arthritis and treated with OLT1177 (200 mg/kg). Percent change was calculated as described in the Methods section of text. n = 8 per group; **** p < 0.0001, ** p < 0.01, * p < 0.05