Fig. 2

Dose-dependent effects of OLT1177 on mice subjected to zymosan-induced arthritis. a Mean ± SEM of joint score (n = 10) in mice treated with 60, 200, or 600 mg/kg of OLT1177. b Plasma levels (μg/ml) of OLT1177 in mice (n = 4–5 per group) treated with 60 (p < 0.01), 200 (p < 0.0001), or 600 mg/kg (p < 0.0001) of OLT1177. ^# 600 mg/kg vs 200 mg/kg, *** p < 0.001, ** p < 0.01, p < 0.05