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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

Fig. 5

Effect of OLT1177-enriched diet in monosodium urate (MSU)-induced arthritis. a Mean ± SEM of joint score (n = 9–10). b and c Mean ± SEM of interleukin (IL)-1β and IL-6 in synovial tissue lysates from mice subjected to experimental MSU-induced arthritis (n = 9–10 per group). d Western blot for NLRP3 and IL-1β (p17 and IL-1β precursor p37) in synovial tissue lysates from mice subjected to experimental MSU-induced arthritis and fed a standard diet or an OLT1177-enriched diet. Each lane represents a single mouse. e and f Fold change of messenger RNA (mRNA) levels of nlrp3 and il1b of synovial tissue extracts from mice treated with OLT1177 (n = 4–5 per group). **** p < 0.0001, ** p < 0.01, * p < 0.05

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