From: The relationship between ferritin and urate levels and risk of gout
MR analysis | Phenotype | Gene/locus | Genetic variant | estimate | SE | (95% CI) | p-causal | Q–p | MR Egger_HP | ||
---|---|---|---|---|---|---|---|---|---|---|---|
Exposure | Outcome | intercept | p value | ||||||||
Wald ratio | Iron | Urate | TF | rs1525892 | 0.127 | 0.076 | (− 0.02; 0.28) | 0.093 | – | – | – |
– | Iron | Urate | HFE | rs1800562 | 0.107 | 0.032 | (0.04; 0.17) | 0.0008 | – | – | – |
– | Iron | Urate | TMPRSS6 | rs855791 | − 0.001 | 0.031 | (− 0.06; 0.06) | 0.99 | – | – | – |
IVW | Iron | Urate | – | All | 0.056 | 0.039 | (− 0.02; 0.13) | 0.15 | 0.179 | – | – |
MR Egger | Iron | Urate | – | All | 0.064 | 0.109 | (− 0.15; 0.28) | 0.61 | 0.011 | − 0.0016 | 0.95 |
Wald ratio | Log ferritin | Urate | SLC40A1 | rs12693541 | − 0.068 | 0.076 | (− 0.22; 0.08) | 0.37 | – | – | – |
– | Log ferritin | Urate | HFE | rs1800562 | 0.190 | 0.057 | (0.08; 0.30) | 0.0002 | – | – | – |
– | Log ferritin | Urate | TMPRSS6 | rs2413450 | 0.011 | 0.106 | (− 0.20; 0.22) | 0.92 | – | – | – |
– | Log ferritin | Urate | TEX14 | rs411988 | − 0.048 | 0.123 | (− 0.29; 0.19) | 0.70 | – | – | – |
– | Log ferritin | Urate | ABO | rs651007 | 0.320 | 0.140 | (0.05; 0.59) | 0.022 | – | – | – |
IVW | Log ferritin | Urate | – | All | 0.089 | 0.066 | (− 0.04; 0.22) | 0.18 | 0.063 | – | – |
MR Egger | Log ferritin | Urate | – | All | 0.160 | 0.134 | (− 0.10; 0.42) | 0.32 | 0.014 | − 0.0067 | 0.58 |