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Table 5 Association between iron/ferritin and urate using two-sample Mendelian randomization

From: The relationship between ferritin and urate levels and risk of gout

MR analysis Phenotype Gene/locus Genetic variant estimate SE (95% CI) p-causal Q–p MR Egger_HP
Exposure Outcome intercept p value
Wald ratio Iron Urate TF rs1525892 0.127 0.076 (− 0.02; 0.28) 0.093
Iron Urate HFE rs1800562 0.107 0.032 (0.04; 0.17) 0.0008
Iron Urate TMPRSS6 rs855791 − 0.001 0.031 (− 0.06; 0.06) 0.99
IVW Iron Urate All 0.056 0.039 (− 0.02; 0.13) 0.15 0.179
MR Egger Iron Urate All 0.064 0.109 (− 0.15; 0.28) 0.61 0.011 − 0.0016 0.95
Wald ratio Log ferritin Urate SLC40A1 rs12693541 − 0.068 0.076 (− 0.22; 0.08) 0.37
Log ferritin Urate HFE rs1800562 0.190 0.057 (0.08; 0.30) 0.0002
Log ferritin Urate TMPRSS6 rs2413450 0.011 0.106 (− 0.20; 0.22) 0.92
Log ferritin Urate TEX14 rs411988 − 0.048 0.123 (− 0.29; 0.19) 0.70
Log ferritin Urate ABO rs651007 0.320 0.140 (0.05; 0.59) 0.022
IVW Log ferritin Urate All 0.089 0.066 (− 0.04; 0.22) 0.18 0.063
MR Egger Log ferritin Urate All 0.160 0.134 (− 0.10; 0.42) 0.32 0.014 − 0.0067 0.58
  1. All beta estimates presented as an effect of per standard deviation unit change in iron and ferritin on change in urate (mg dl−1)
  2. MR Mendelian randomization, SE standard error, CI confidence interval, p-causal p value using MR analysis, Q–p Cochran’s heterogeneity test showing p value for heterogeneity, MR Egger_HP Egger test for horizontal pleiotropy, IVW meta-analysis using inverse-variance method, MR Egger Mendelian randomization using Egger regression