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Table 5 Association between iron/ferritin and urate using two-sample Mendelian randomization

From: The relationship between ferritin and urate levels and risk of gout

MR analysis

Phenotype

Gene/locus

Genetic variant

estimate

SE

(95% CI)

p-causal

Q–p

MR Egger_HP

Exposure

Outcome

intercept

p value

Wald ratio

Iron

Urate

TF

rs1525892

0.127

0.076

(− 0.02; 0.28)

0.093

–

–

–

–

Iron

Urate

HFE

rs1800562

0.107

0.032

(0.04; 0.17)

0.0008

–

–

–

–

Iron

Urate

TMPRSS6

rs855791

− 0.001

0.031

(− 0.06; 0.06)

0.99

–

–

–

IVW

Iron

Urate

–

All

0.056

0.039

(− 0.02; 0.13)

0.15

0.179

–

–

MR Egger

Iron

Urate

–

All

0.064

0.109

(− 0.15; 0.28)

0.61

0.011

− 0.0016

0.95

Wald ratio

Log ferritin

Urate

SLC40A1

rs12693541

− 0.068

0.076

(− 0.22; 0.08)

0.37

–

–

–

–

Log ferritin

Urate

HFE

rs1800562

0.190

0.057

(0.08; 0.30)

0.0002

–

–

–

–

Log ferritin

Urate

TMPRSS6

rs2413450

0.011

0.106

(− 0.20; 0.22)

0.92

–

–

–

–

Log ferritin

Urate

TEX14

rs411988

− 0.048

0.123

(− 0.29; 0.19)

0.70

–

–

–

–

Log ferritin

Urate

ABO

rs651007

0.320

0.140

(0.05; 0.59)

0.022

–

–

–

IVW

Log ferritin

Urate

–

All

0.089

0.066

(− 0.04; 0.22)

0.18

0.063

–

–

MR Egger

Log ferritin

Urate

–

All

0.160

0.134

(− 0.10; 0.42)

0.32

0.014

− 0.0067

0.58

  1. All beta estimates presented as an effect of per standard deviation unit change in iron and ferritin on change in urate (mg dl−1)
  2. MR Mendelian randomization, SE standard error, CI confidence interval, p-causal p value using MR analysis, Q–p Cochran’s heterogeneity test showing p value for heterogeneity, MR Egger_HP Egger test for horizontal pleiotropy, IVW meta-analysis using inverse-variance method, MR Egger Mendelian randomization using Egger regression