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Table 6 Leave-one-out sensitivity analysis for association between iron/ferritin and urate using inverse-variance weighted two-sample Mendelian randomization

From: The relationship between ferritin and urate levels and risk of gout

Phenotype

Instrumental variant excluded from IVW analysis

β estimate

(95% CI)

p-causal

Exposure

Outcome

Iron

Urate

TF rs1525892

0.050

(− 0.06; 0.16)

0.35

Iron

Urate

HFE rs1800562

0.017

(− 0.07; 0.10)

0.70

Iron

Urate

TMPRSS6 rs855791

0.110

(0.05; 0.17)

2.0E–04

Iron

Urate

All

0.050

(− 0.02; 0.13)

0.15

Log ferritin

Urate

SLC40A1 rs12693541

0.141

(0.02; 0.27)

0.027

Log ferritin

Urate

HFE rs1800562

0.007

(− 0.14; 0.15)

0.93

Log ferritin

Urate

TMPRSS6 rs2413450

0.101

(− 0.05; 0.26)

0.20

Log ferritin

Urate

TEX14 rs411988

0.103

(− 0.04; 0.25)

0.17

Log ferritin

Urate

ABO rs651007

0.070

(− 0.06; 0.20)

0.30

Log ferritin

Urate

All

0.089

(− 0.04; 0.22)

0.18

  1. All beta estimates presented as an effect of per standard deviation unit change in iron and ferritin on change in urate (mg dl−1)
  2. IVW meta-analysis using inverse-variance method, CI confidence interval, p-causal p value using IVW meta-analysis, HFE human hemochromatosis protein, TMPRSS6 transmembrane protease serine-6, ABO alpha 1–3-N-acetylgalactosaminyltransferase