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Table 6 Leave-one-out sensitivity analysis for association between iron/ferritin and urate using inverse-variance weighted two-sample Mendelian randomization

From: The relationship between ferritin and urate levels and risk of gout

Phenotype Instrumental variant excluded from IVW analysis β estimate (95% CI) p-causal
Exposure Outcome
Iron Urate TF rs1525892 0.050 (− 0.06; 0.16) 0.35
Iron Urate HFE rs1800562 0.017 (− 0.07; 0.10) 0.70
Iron Urate TMPRSS6 rs855791 0.110 (0.05; 0.17) 2.0E–04
Iron Urate All 0.050 (− 0.02; 0.13) 0.15
Log ferritin Urate SLC40A1 rs12693541 0.141 (0.02; 0.27) 0.027
Log ferritin Urate HFE rs1800562 0.007 (− 0.14; 0.15) 0.93
Log ferritin Urate TMPRSS6 rs2413450 0.101 (− 0.05; 0.26) 0.20
Log ferritin Urate TEX14 rs411988 0.103 (− 0.04; 0.25) 0.17
Log ferritin Urate ABO rs651007 0.070 (− 0.06; 0.20) 0.30
Log ferritin Urate All 0.089 (− 0.04; 0.22) 0.18
  1. All beta estimates presented as an effect of per standard deviation unit change in iron and ferritin on change in urate (mg dl−1)
  2. IVW meta-analysis using inverse-variance method, CI confidence interval, p-causal p value using IVW meta-analysis, HFE human hemochromatosis protein, TMPRSS6 transmembrane protease serine-6, ABO alpha 1–3-N-acetylgalactosaminyltransferase