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Table 2 Univariable associations between a positive family history and HLA-B27 carriership in patients suspected of axial spondyloarthritis (n = 594)

From: Do ethnicity, degree of family relationship, and the spondyloarthritis subtype in affected relatives influence the association between a positive family history for spondyloarthritis and HLA-B27 carriership? Results from the worldwide ASAS cohort

 

HLA-B27+ (n = 310)

HLA-B27− (n = 284)

OR (95% CI)

p Value

Positive family history according to ASAS definition

 Stratified by self-reported ethnicity

  White

54

26

2.3 (1.4–3.9)

0.001

  Asian

38

14

3.1 (1.6–5.8)

0.001

  Other ethnicitiesa

2

1

2.3 (0.2–25.0)

0.509

 Stratified by degree of family relationship

  First-degree relatives

79

31

2.9 (1.8–4.5)

< 0.001

  Only second-degree relatives

15

10

1.7 (0.7–3.8)

0.212

Positive family history of AS

 Stratified by self-reported ethnicity

  White

37

6

7.1 (2.9–17.1)

< 0.001

  Asian

35

7

5.7 (2.5–13.2)

< 0.001

  Other ethnicitiesa

2

0

n.a.

n.a.

 Stratified by degree of family relationship

  First-degree relatives

61

9

7.8 (3.8–16.0)

< 0.001

  Only second-degree relatives

13

4

3.7 (1.2–11.6)

0.023

Positive family history of AAU

 Stratified by self-reported ethnicity

  White

4

0

n.a.

n.a.

  Asian

2

1

1.9 (0.2–20.7)

0.613

  Other ethnicitiesa

0

0

n.a.

n.a.

 Stratified by degree of family relationship

  First-degree relatives

5

1

4.7 (0.5–40.1)

0.162

  Only second-degree relatives

1

0

n.a.

n.a.

Positive family history of ReA

 Stratified by self-reported ethnicity

  White

2

2

0.9 (0.1–6.5)

0.924

  Asian

1

3

0.3 (0.03–2.9)

0.302

  Other ethnicitiesa

0

0

n.a.

n.a.

 Stratified by degree of family relationship

  First-degree relatives

3

2

1.4 (0.2–8.2)

0.735

  Only second-degree relatives

0

3

n.a

n.a

Positive family history of IBD

 Stratified by self-reported ethnicity

  White

2

7

0.3 (0.05–1.2)

0.089

  Asian

0

2

n.a.

n.a.

  Other ethnicitiesa

0

1

n.a.

n.a.

 Stratified by degree of family relationship

  First-degree relatives

1

7

0.1 (0.02–1.0)

0.054

  Only second-degree relatives

1

3

0.3 (0.03–2.9)

0.294

Positive family history of psoriasis

 Stratified by self-reported ethnicity

  White

16

15

1.0 (0.5–2.0)

0.938

  Asian

2

2

0.9 (0.1–6.5)

0.926

  Other ethnicitiesa

0

1

n.a.

n.a.

 Stratified by degree of family relationship

  First-degree relatives

15

14

1.0 (0.5–2.1)

0.949

  Only second-degree relatives

3

4

0.7 (0.2–3.1)

0.620

  1. Statistically significant results are printed in bold
  2. Abbreviations: AAU Acute anterior uveitis, AS Ankylosing spondylitis, HLA-B27 Human leukocyte antigen B27, IBD Inflammatory bowel disease, n.a. Not applicable, ReA Reactive arthritis
  3. aSelf-reported ethnicities was missing for five patients, who are included in this category, and other ethnicities are black, East Indian, Hispanic/Latino, mixed, or Turkish
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Arthritis Research & Therapy

ISSN: 1478-6362

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