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Table 2 Univariable associations between a positive family history and HLA-B27 carriership in patients suspected of axial spondyloarthritis (n = 594)

From: Do ethnicity, degree of family relationship, and the spondyloarthritis subtype in affected relatives influence the association between a positive family history for spondyloarthritis and HLA-B27 carriership? Results from the worldwide ASAS cohort

  HLA-B27+ (n = 310) HLA-B27− (n = 284) OR (95% CI) p Value
Positive family history according to ASAS definition
 Stratified by self-reported ethnicity
  White 54 26 2.3 (1.4–3.9) 0.001
  Asian 38 14 3.1 (1.6–5.8) 0.001
  Other ethnicitiesa 2 1 2.3 (0.2–25.0) 0.509
 Stratified by degree of family relationship
  First-degree relatives 79 31 2.9 (1.8–4.5) < 0.001
  Only second-degree relatives 15 10 1.7 (0.7–3.8) 0.212
Positive family history of AS
 Stratified by self-reported ethnicity
  White 37 6 7.1 (2.9–17.1) < 0.001
  Asian 35 7 5.7 (2.5–13.2) < 0.001
  Other ethnicitiesa 2 0 n.a. n.a.
 Stratified by degree of family relationship
  First-degree relatives 61 9 7.8 (3.8–16.0) < 0.001
  Only second-degree relatives 13 4 3.7 (1.2–11.6) 0.023
Positive family history of AAU
 Stratified by self-reported ethnicity
  White 4 0 n.a. n.a.
  Asian 2 1 1.9 (0.2–20.7) 0.613
  Other ethnicitiesa 0 0 n.a. n.a.
 Stratified by degree of family relationship
  First-degree relatives 5 1 4.7 (0.5–40.1) 0.162
  Only second-degree relatives 1 0 n.a. n.a.
Positive family history of ReA
 Stratified by self-reported ethnicity
  White 2 2 0.9 (0.1–6.5) 0.924
  Asian 1 3 0.3 (0.03–2.9) 0.302
  Other ethnicitiesa 0 0 n.a. n.a.
 Stratified by degree of family relationship
  First-degree relatives 3 2 1.4 (0.2–8.2) 0.735
  Only second-degree relatives 0 3 n.a n.a
Positive family history of IBD
 Stratified by self-reported ethnicity
  White 2 7 0.3 (0.05–1.2) 0.089
  Asian 0 2 n.a. n.a.
  Other ethnicitiesa 0 1 n.a. n.a.
 Stratified by degree of family relationship
  First-degree relatives 1 7 0.1 (0.02–1.0) 0.054
  Only second-degree relatives 1 3 0.3 (0.03–2.9) 0.294
Positive family history of psoriasis
 Stratified by self-reported ethnicity
  White 16 15 1.0 (0.5–2.0) 0.938
  Asian 2 2 0.9 (0.1–6.5) 0.926
  Other ethnicitiesa 0 1 n.a. n.a.
 Stratified by degree of family relationship
  First-degree relatives 15 14 1.0 (0.5–2.1) 0.949
  Only second-degree relatives 3 4 0.7 (0.2–3.1) 0.620
  1. Statistically significant results are printed in bold
  2. Abbreviations: AAU Acute anterior uveitis, AS Ankylosing spondylitis, HLA-B27 Human leukocyte antigen B27, IBD Inflammatory bowel disease, n.a. Not applicable, ReA Reactive arthritis
  3. aSelf-reported ethnicities was missing for five patients, who are included in this category, and other ethnicities are black, East Indian, Hispanic/Latino, mixed, or Turkish