Fig. 6

Path-net analysis of differentially signaling pathways. Nodes represent different pathways; red indicates upregulated, blue indicates downregulated, and yellow indicates both upregulated and downregulated. The size of each circle is determined by the number of other genes that interact with this gene, namely the degree of the pathway. ECM, extracellular matrix; MAPK, mitogen-activated protein kinase; VEGF vascular endothelial growth factor; TGF, transforming growth factor