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Table 2 Odds ratios of rheumatoid arthritis by categories of the Mediterranean diet score among participants of the EIRA study (n = 1721 patients with RA (cases) and n = 3667 controls)

From: Mediterranean diet and risk of rheumatoid arthritis: a population-based case-control study

  Mediterranean-diet score
0–2 3 4–5 6–9
Overall
 Number 351/574 327/636 629/1424 414/1033
 OR crude Ref 0.87 (0.71–1.05) 0.74 (0.62–0.87) 0.66 (0.55–0.79)
 OR adjusted Ref 0.93 (0.76–1.14) 0.83 (0.69–0.99) 0.79 (0.65–0.96)
Female
 Number 228/411 242/441 458/1026 323/769
 OR crude Ref 1.01 (0.80–1.28) 0.81 (0.66–0.99) 0.77 (0.62–0.95)
 OR adjusted Ref 1.09 (0.85–1.39) 0.92 (0.75–1.14) 0.94 (0.74–1.18)
 OR adjusted 2 Ref 1.07 (0.84–1.37) 0.91 (0.73–1.12) 0.94 (0.74–1.18)
Male
 Number 123/167 84/195 171/398 91/264
 OR crude Ref 0.61 (0.43–0.87) 0.59 (0.43–0.80) 0.45 (0.32–0.64)
 OR adjusted Ref 0.65 (0.45–0.95) 0.62 (0.45–0.87) 0.49 (0.33–0.73)
RF positive
 Numbe 238/327 232/356 401/841 248/627
 OR crude Ref 0.90 (0.70–1.14) 0.66 (0.54–0.81) 0.55 (0.44–0.69)
 OR adjusted Ref 0.97 (0.75–1.25) 0.76 (0.61–0.95) 0.69 (0.54–0.88)
RF negative
 Number 113/184 90/205 226/422 163/307
 OR crude Ref 0.77 (0.55–1.08) 0.91 (0.68–1.21) 0.89 (0.66–1.21)
 OR adjusted Ref 0.80 (0.56–1.14) 0.93 (0.68–1.27) 0.96 (0.68–1.34)
ACPA positive
 Number 247/343 240/387 424/863 264/646
 OR crude Ref 0.87 (0.69–1.10) 0.68 (0.56–0.83) 0.58 (0.47–0.72)
 OR adjusted Ref 0.95 (0.74–1.21) 0.78 (0.63–0.97) 0.72 (0.57–0.92)
ACPA negative
 Number 103/170 84/176 203/403 149/279
 OR crude Ref 0.84 (0.58–1.20) 0.88 (0.65–1.19) 0.91 (0.66–1.26)
 OR adjusted Ref 0.89 (0.61–1.30) 0.93 (0.67–1.29) 1.00 (0.70–1.42)
  1. Odds ratio (OR) crude was conditioned on age, gender and residential area. OR adjusted was adjusted for smoking, physical activity, education level, body mass index, energy intake and supplements use. OR adjusted 2 was additionally adjusted for parity, use of oral contraceptive, use of hormone replacement therapy and age at menarche
  2. RA rheumatoid arthritis, ACPA antibodies to citrullinated peptides, Ref reference