Table 2 Association of IFNL3/4 SNPs with SLE susceptibility
SNP | Risk allele frequency | Genotype frequency | P Trend a | P FDR | Unadjustedb | Adjusted for sex and ageb | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
P | P FDR | OR (95% CI) | P | P FDR | OR (95% CI) | |||||||
rs8099917T > G | G | GG | GT | TT | ||||||||
SLE | 129 (7.76%) | 3 (0.36%) | 123 (14.8%) | 705 (84.84%) | 0.0035 | 0.009 | 0.0033 | 0.0084 | 1.42 (1.12–1.79) | 0.1144 | 0.1144 | 1.26 (0.95–1.67) |
Nephritis negative | 75 (10.14%) | 2 (0.54%) | 71 (19.19%) | 297 (80.27%) | 0 | 0 | 8.57E–06 | 2.14E–05 | 1.90 (1.43–2.52) | 0.00077 | 0.00177 | 1.68 (1.24–2.28) |
Nephritis positive | 54 (5.86%) | 1 (0.22%) | 52 (11.28%) | 408 (88.50%) | 0.7508 | 0.9401 | 0.74389 | 0.90622 | 1.05 (0.77–1.44) | 0.91081 | 0.99622 | 1.02 (0.72–1.44) |
Control | 181 (5.57%) | 8 (0.49%) | 165 (10.16%) | 1451 (89.35%) | ||||||||
rs12979860C > T | T | CC | CT | TT | ||||||||
SLE | 133 (8%) | 702 (84.48%) | 125 (15.04%) | 4 (0.48%) | 0.0135 | 0.0225 | 0.0121 | 0.0202 | 1.34 (1.07–1.67) | 0.0968 | 0.1144 | 1.26 (0.96–1.66) |
Nephritis negative | 76 (10.27%) | 297 (80.27%) | 70 (18.92%) | 3 (0.81%) | 0.0004 | 0.0005 | 7.19E–05 | 8.99E–05 | 1.75 (1.33–2.30) | 0.00239 | 0.00299 | 1.58 (1.18–2.12) |
Nephritis positive | 57 (6.18%) | 405 (87.85%) | 55 (11.93%) | 1 (0.22%) | 0.9401 | 0.9401 | 0.89714 | 0.90622 | 1.02 (0.76–1.38) | 0.87007 | 0.99622 | 1.03 (0.74–1.43) |
Control | 197 (6.07%) | 1437 (88.49%) | 177 (10.90%) | 10 (0.62%) | ||||||||
rs4803217C > A | A | AA | AC | CC | ||||||||
SLE | 131 (7.88%) | 3 (0.36%) | 125 (15.04%) | 703 (84.6%) | 0.0036 | 0.009 | 0.0029 | 0.0084 | 1.43 (1.13–1.8) | 0.0386 | 0.1137 | 1.35 (1.02–1.8) |
Nephritis negative | 76 (10.27%) | 2 (0.54%) | 72 (19.46%) | 296 (80.00%) | 0 | 0 | 2.37E–05 | 3.96E–05 | 1.82 (1.38–2.41) | 0.00106 | 0.00176 | 1.65 (1.22–2.23) |
Nephritis positive | 55 (5.97%) | 1 (0.22%) | 53 (11.50%) | 407 (88.29%) | 0.9368 | 0.9401 | 0.90622 | 0.90622 | 1.02 (0.75–1.38) | 0.99622 | 0.99622 | 1.00 (0.71–1.40) |
Control | 190 (5.86%) | 9 (0.56%) | 172 (10.61%) | 1440 (88.83%) | ||||||||
ss469415590TT>ΔGb | ΔG | ΔG/ΔG | ΔG/TT | TT/TT | ||||||||
SLE | 142 (8.6%) | 10 (1.21%) | 122 (14.77%) | 694 (84.02%) | 0.0293 | 0.0367 | 1.26 (1.02–1.55) | 0.0571 | 0.1137 | 1.28 (0.99–1.65) | ||
Nephritis negative | 76 (10.35%) | 3(0.82%) | 70 (19.07%) | 294 (80.11%) | 0 | 0 | 7.87E–06 | 2.14E–05 | 1.89 (1.43–2.50) | 0.00058 | 0.00176 | 1.70 (1.26–2.29) |
Nephritis positive | 54 (5.88%) | 1 (0.22%) | 52 (11.33%) | 406 (88.45%) | 0.875 | 0.9401 | 0.83482 | 0.90622 | 1.03 (0.76–1.41) | 0.98182 | 0.99622 | 1.00 (0.71–1.40) |
Control | 185 (5.70%) | 8 (0.49%) | 169 (10.41%) | 1446 (89.09%) | ||||||||