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Table 2 Association of IFNL3/4 SNPs with SLE susceptibility

From: Interferon-λ3/4 genetic variants and interferon-λ3 serum levels are biomarkers of lupus nephritis and disease activity in Taiwanese

SNP Risk allele frequency Genotype frequency P Trend a P FDR Unadjustedb Adjusted for sex and ageb
P P FDR OR (95% CI) P P FDR OR (95% CI)
rs8099917T > G G GG GT TT         
 SLE 129 (7.76%) 3 (0.36%) 123 (14.8%) 705 (84.84%) 0.0035 0.009 0.0033 0.0084 1.42 (1.12–1.79) 0.1144 0.1144 1.26 (0.95–1.67)
  Nephritis negative 75 (10.14%) 2 (0.54%) 71 (19.19%) 297 (80.27%) 0 0 8.57E–06 2.14E–05 1.90 (1.43–2.52) 0.00077 0.00177 1.68 (1.24–2.28)
  Nephritis positive 54 (5.86%) 1 (0.22%) 52 (11.28%) 408 (88.50%) 0.7508 0.9401 0.74389 0.90622 1.05 (0.77–1.44) 0.91081 0.99622 1.02 (0.72–1.44)
 Control 181 (5.57%) 8 (0.49%) 165 (10.16%) 1451 (89.35%)         
rs12979860C > T T CC CT TT         
 SLE 133 (8%) 702 (84.48%) 125 (15.04%) 4 (0.48%) 0.0135 0.0225 0.0121 0.0202 1.34 (1.07–1.67) 0.0968 0.1144 1.26 (0.96–1.66)
  Nephritis negative 76 (10.27%) 297 (80.27%) 70 (18.92%) 3 (0.81%) 0.0004 0.0005 7.19E–05 8.99E–05 1.75 (1.33–2.30) 0.00239 0.00299 1.58 (1.18–2.12)
  Nephritis positive 57 (6.18%) 405 (87.85%) 55 (11.93%) 1 (0.22%) 0.9401 0.9401 0.89714 0.90622 1.02 (0.76–1.38) 0.87007 0.99622 1.03 (0.74–1.43)
 Control 197 (6.07%) 1437 (88.49%) 177 (10.90%) 10 (0.62%)         
rs4803217C > A A AA AC CC         
 SLE 131 (7.88%) 3 (0.36%) 125 (15.04%) 703 (84.6%) 0.0036 0.009 0.0029 0.0084 1.43 (1.13–1.8) 0.0386 0.1137 1.35 (1.02–1.8)
  Nephritis negative 76 (10.27%) 2 (0.54%) 72 (19.46%) 296 (80.00%) 0 0 2.37E–05 3.96E–05 1.82 (1.38–2.41) 0.00106 0.00176 1.65 (1.22–2.23)
  Nephritis positive 55 (5.97%) 1 (0.22%) 53 (11.50%) 407 (88.29%) 0.9368 0.9401 0.90622 0.90622 1.02 (0.75–1.38) 0.99622 0.99622 1.00 (0.71–1.40)
 Control 190 (5.86%) 9 (0.56%) 172 (10.61%) 1440 (88.83%)         
ss469415590TT>ΔGb ΔG ΔG/ΔG ΔG/TT TT/TT         
 SLE 142 (8.6%) 10 (1.21%) 122 (14.77%) 694 (84.02%)    0.0293 0.0367 1.26 (1.02–1.55) 0.0571 0.1137 1.28 (0.99–1.65)
  Nephritis negative 76 (10.35%) 3(0.82%) 70 (19.07%) 294 (80.11%) 0 0 7.87E–06 2.14E–05 1.89 (1.43–2.50) 0.00058 0.00176 1.70 (1.26–2.29)
  Nephritis positive 54 (5.88%) 1 (0.22%) 52 (11.33%) 406 (88.45%) 0.875 0.9401 0.83482 0.90622 1.03 (0.76–1.41) 0.98182 0.99622 1.00 (0.71–1.40)
 Control 185 (5.70%) 8 (0.49%) 169 (10.41%) 1446 (89.09%)         
  1. Data presented as n (%)
  2. SLE systemic lupus erythematosus, SNP single-nucleotide polymorphism, OR odds ratio, CI confidence interval
  3. aTrend test P values generated from 10,000 permutations
  4. bAdditive model used to test mode of inheritance