SNP
|
Risk allele frequency
|
Genotype frequency
|
P
Trend
a
|
P
FDR
|
Unadjustedb
|
Adjusted for sex and ageb
|
---|
P
|
P
FDR
|
OR (95% CI)
|
P
|
P
FDR
|
OR (95% CI)
|
---|
rs8099917T > G
|
G
|
GG
|
GT
|
TT
| | | | | | | | |
SLE
|
129 (7.76%)
|
3 (0.36%)
|
123 (14.8%)
|
705 (84.84%)
|
0.0035
|
0.009
|
0.0033
|
0.0084
|
1.42 (1.12–1.79)
|
0.1144
|
0.1144
|
1.26 (0.95–1.67)
|
Nephritis negative
|
75 (10.14%)
|
2 (0.54%)
|
71 (19.19%)
|
297 (80.27%)
|
0
|
0
|
8.57E–06
|
2.14E–05
|
1.90 (1.43–2.52)
|
0.00077
|
0.00177
|
1.68 (1.24–2.28)
|
Nephritis positive
|
54 (5.86%)
|
1 (0.22%)
|
52 (11.28%)
|
408 (88.50%)
|
0.7508
|
0.9401
|
0.74389
|
0.90622
|
1.05 (0.77–1.44)
|
0.91081
|
0.99622
|
1.02 (0.72–1.44)
|
Control
|
181 (5.57%)
|
8 (0.49%)
|
165 (10.16%)
|
1451 (89.35%)
| | | | | | | | |
rs12979860C > T
|
T
|
CC
|
CT
|
TT
| | | | | | | | |
SLE
|
133 (8%)
|
702 (84.48%)
|
125 (15.04%)
|
4 (0.48%)
|
0.0135
|
0.0225
|
0.0121
|
0.0202
|
1.34 (1.07–1.67)
|
0.0968
|
0.1144
|
1.26 (0.96–1.66)
|
Nephritis negative
|
76 (10.27%)
|
297 (80.27%)
|
70 (18.92%)
|
3 (0.81%)
|
0.0004
|
0.0005
|
7.19E–05
|
8.99E–05
|
1.75 (1.33–2.30)
|
0.00239
|
0.00299
|
1.58 (1.18–2.12)
|
Nephritis positive
|
57 (6.18%)
|
405 (87.85%)
|
55 (11.93%)
|
1 (0.22%)
|
0.9401
|
0.9401
|
0.89714
|
0.90622
|
1.02 (0.76–1.38)
|
0.87007
|
0.99622
|
1.03 (0.74–1.43)
|
Control
|
197 (6.07%)
|
1437 (88.49%)
|
177 (10.90%)
|
10 (0.62%)
| | | | | | | | |
rs4803217C > A
|
A
|
AA
|
AC
|
CC
| | | | | | | | |
SLE
|
131 (7.88%)
|
3 (0.36%)
|
125 (15.04%)
|
703 (84.6%)
|
0.0036
|
0.009
|
0.0029
|
0.0084
|
1.43 (1.13–1.8)
|
0.0386
|
0.1137
|
1.35 (1.02–1.8)
|
Nephritis negative
|
76 (10.27%)
|
2 (0.54%)
|
72 (19.46%)
|
296 (80.00%)
|
0
|
0
|
2.37E–05
|
3.96E–05
|
1.82 (1.38–2.41)
|
0.00106
|
0.00176
|
1.65 (1.22–2.23)
|
Nephritis positive
|
55 (5.97%)
|
1 (0.22%)
|
53 (11.50%)
|
407 (88.29%)
|
0.9368
|
0.9401
|
0.90622
|
0.90622
|
1.02 (0.75–1.38)
|
0.99622
|
0.99622
|
1.00 (0.71–1.40)
|
Control
|
190 (5.86%)
|
9 (0.56%)
|
172 (10.61%)
|
1440 (88.83%)
| | | | | | | | |
ss469415590TT>ΔGb
|
ΔG
|
ΔG/ΔG
|
ΔG/TT
|
TT/TT
| | | | | | | | |
SLE
|
142 (8.6%)
|
10 (1.21%)
|
122 (14.77%)
|
694 (84.02%)
| | |
0.0293
|
0.0367
|
1.26 (1.02–1.55)
|
0.0571
|
0.1137
|
1.28 (0.99–1.65)
|
Nephritis negative
|
76 (10.35%)
|
3(0.82%)
|
70 (19.07%)
|
294 (80.11%)
|
0
|
0
|
7.87E–06
|
2.14E–05
|
1.89 (1.43–2.50)
|
0.00058
|
0.00176
|
1.70 (1.26–2.29)
|
Nephritis positive
|
54 (5.88%)
|
1 (0.22%)
|
52 (11.33%)
|
406 (88.45%)
|
0.875
|
0.9401
|
0.83482
|
0.90622
|
1.03 (0.76–1.41)
|
0.98182
|
0.99622
|
1.00 (0.71–1.40)
|
Control
|
185 (5.70%)
|
8 (0.49%)
|
169 (10.41%)
|
1446 (89.09%)
| | | | | | | | |
- Data presented as n (%)
- SLE systemic lupus erythematosus, SNP single-nucleotide polymorphism, OR odds ratio, CI confidence interval
- aTrend test P values generated from 10,000 permutations
- bAdditive model used to test mode of inheritance