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Table 3 Association of IFNL3/4 SNPs with lupus nephritis among SLE patients

From: Interferon-λ3/4 genetic variants and interferon-λ3 serum levels are biomarkers of lupus nephritis and disease activity in Taiwanese

SNP

Risk allele frequency

Genotype frequency

P Trend a

P FDR

Test for mode of inheritance unadjusted

Test for mode of inheritance adjusted for sex and age

 

P

P FDR

OR (95% CI)

 

P

P FDR

OR (95% CI)

rs8099917T > G

T

GG

GT

TT

  

Additive

0.0018

0.0024

1.73 (1.23–2.45)

Additive

0.0016

0.0021

1.75 (1.24–2.47)

 Nephritis+

1058 (94.30%)

1 (0.18%)

62 (11.05%)

498 (88.77%)

0.001

0.0016

TT + GT vs GG

0.45681

0.657

2.49 (0.23–27.60)

TT vs GT + GG

0.4705

0.684

2.42 (0.22–26.82)

  Cohort 1

868 (94.14%)

1 (0.22%)

52 (11.28%)

408 (88.5%)

          

  Cohort 2

190 (95.00%)

0 (0.00%)

10 (10.00%)

90 (90.00%)

          

 Nephritis−

818 (90.69%)

2 (0.44%)

80 (17.74%)

369 (81.82%)

  

TT vs GT + GG

0.0019

0.0025

1.76 (1.23–2.50)

TT + GT vs GG

0.0016

0.0022

1.77 (1.24–2.53)

  Cohort 1

665 (89.86%)

2 (0.54%)

71 (19.19%)

297 (80.27%)

          

  Cohort 2

153 (94.44%)

0 (0.00%)

9 (11.11%)

72 (88.89%)

          

rs12979860T > C

C

CC

CT

TT

  

Additive

0.0036

0.0036

1.64 (1.18–2.29)

Additive

0.0034

0.0034

1.65 (1.18–2.30)

 Nephritis+

1053 (93.85%)

494 (88.06%)

65 (11.59%)

2 (0.36%)

0.0042

0.0042

CC + CT vs TT

0.4949

0.4949

1.87 (0.31–11.22)

CC vs CT + TT

0.5153

0.5153

1.81 (0.30–10.91)

  Cohort 1

865 (93.82%)

405 (87.85%)

55 (11.93%)

1 (0.22%)

          

  Cohort 2

188 (94.00%)

89 (89.00%)

10 (10.00%)

1 (1.00%)

          

 Nephritis−

817 (90.38%)

368 (81.42%)

81 (17.92%)

3 (0.66%)

  

CC vs CT + TT

0.0034

0.0136

1.68(1.19–2.38)

CC + CT vs TT

0.0031

0.0123

1.69 (1.19–2.40)

  Cohort 1

664 (89.73%)

297 (80.27%)

70 (18.92%)

3 (0.81%)

          

  Cohort 2

153 (93.29%)

71 (86.59%)

11 (13.41%)

0 (0.00%)

          

rs4803217C > A

C

AA

AC

CC

  

Additive

0.0012

0.0024

1.76(1.25–2.47)

Additive

0.0011

0.0021

1.76 (1.25–2.48)

 Nephritis+

1055 (94.20%)

2 (0.36%)

61 (10.89%)

497 (88.75%)

0.0012

0.0016

CC + AC vs AA

0.8300

0.83

1.24 (0.17–8.84)

CC vs AC + AA

0.8531

0.8531

1.20 (0.17–8.58)

  Cohort 1

867 (94.03%)

1 (0.22%)

53 (11.5%)

407 (88.29%)

          

  Cohort 2

188 (94.95%)

1 (1.01%)

8 (8.08%)

90 (90.91%)

          

 Nephritis−

817 (90.38%)

2 (0.44%)

83 (18.36%)

367 (81.19%)

  

CC vs AC + AA

0.0008

0.0025

1.83 (1.28–2.60)

CC + AC vs AA

0.0007

0.0022

1.84 (1.29–2.61)

  Cohort 1

664 (89.73%)

2 (0.54%)

72 (19.46%)

296 (80%)

          

  Cohort 2

153 (93.29%)

0 (0.00%)

11 (13.41%)

71 (86.59%)

          

ss469415590TT>ΔGb

TT

ΔG/ΔG

ΔG/TT

TT/TT

  

Additive

0.0015

0.0024

1.72 (1.23–2.42)

Additive

0.0015

0.0021

1.73(1.23–2.42)

 Nephritis+

1052 (94.10%)

2 (0.36%)

62 (11.09%)

495 (88.55%)

0.0011

0.0016

BB + AB vs AA

0.4927

0.657

1.87 (0.31–11.26)

2TT vs GTT + GG

0.513

0.684

1.82 (0.30–10.94)

  Cohort 1

858 (93.46%)

4 (0.87%)

52 (11.33%)

403 (87.8%)

          

  Cohort 2

188 (94.00%)

1 (1.00%)

10 (10.00%)

89 (89.00%)

          

 Nephritis−

811 (90.31%)

3 (0.67%)

81 (18.04%)

365 (81.29%)

  

BB vs AB + AA

0.0013

0.0025

1.78 (1.25–2.53)

2TT + GTT vs GG

0.0012

0.0022

1.79 (1.26–2.54)

  Cohort 1

652 (88.83%)

6 (1.63%)

70 (19.07%)

291 (79.29%)

          

  Cohort 2

153 (93.29%)

0 (0.00%)

11 (13.41%)

71 (86.59%)

          
  1. Data presented as n (%)
  2. SLE systemic lupus erythematosus, SNP single-nucleotide polymorphism, OR odds ratio, CI confidence interval
  3. aTrend test P values generated from 10,000 permutations
  4. bGenotypes of ΔG/ΔG, ΔG/TT, and TT/TT are also named GG, GTT, and 2TT, respectively
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Arthritis Research & Therapy

ISSN: 1478-6362

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