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Table 3 Association of IFNL3/4 SNPs with lupus nephritis among SLE patients

From: Interferon-λ3/4 genetic variants and interferon-λ3 serum levels are biomarkers of lupus nephritis and disease activity in Taiwanese

SNP Risk allele frequency Genotype frequency P Trend a P FDR Test for mode of inheritance unadjusted Test for mode of inheritance adjusted for sex and age
  P P FDR OR (95% CI)   P P FDR OR (95% CI)
rs8099917T > G T GG GT TT    Additive 0.0018 0.0024 1.73 (1.23–2.45) Additive 0.0016 0.0021 1.75 (1.24–2.47)
 Nephritis+ 1058 (94.30%) 1 (0.18%) 62 (11.05%) 498 (88.77%) 0.001 0.0016 TT + GT vs GG 0.45681 0.657 2.49 (0.23–27.60) TT vs GT + GG 0.4705 0.684 2.42 (0.22–26.82)
  Cohort 1 868 (94.14%) 1 (0.22%) 52 (11.28%) 408 (88.5%)           
  Cohort 2 190 (95.00%) 0 (0.00%) 10 (10.00%) 90 (90.00%)           
 Nephritis 818 (90.69%) 2 (0.44%) 80 (17.74%) 369 (81.82%)    TT vs GT + GG 0.0019 0.0025 1.76 (1.23–2.50) TT + GT vs GG 0.0016 0.0022 1.77 (1.24–2.53)
  Cohort 1 665 (89.86%) 2 (0.54%) 71 (19.19%) 297 (80.27%)           
  Cohort 2 153 (94.44%) 0 (0.00%) 9 (11.11%) 72 (88.89%)           
rs12979860T > C C CC CT TT    Additive 0.0036 0.0036 1.64 (1.18–2.29) Additive 0.0034 0.0034 1.65 (1.18–2.30)
 Nephritis+ 1053 (93.85%) 494 (88.06%) 65 (11.59%) 2 (0.36%) 0.0042 0.0042 CC + CT vs TT 0.4949 0.4949 1.87 (0.31–11.22) CC vs CT + TT 0.5153 0.5153 1.81 (0.30–10.91)
  Cohort 1 865 (93.82%) 405 (87.85%) 55 (11.93%) 1 (0.22%)           
  Cohort 2 188 (94.00%) 89 (89.00%) 10 (10.00%) 1 (1.00%)           
 Nephritis 817 (90.38%) 368 (81.42%) 81 (17.92%) 3 (0.66%)    CC vs CT + TT 0.0034 0.0136 1.68(1.19–2.38) CC + CT vs TT 0.0031 0.0123 1.69 (1.19–2.40)
  Cohort 1 664 (89.73%) 297 (80.27%) 70 (18.92%) 3 (0.81%)           
  Cohort 2 153 (93.29%) 71 (86.59%) 11 (13.41%) 0 (0.00%)           
rs4803217C > A C AA AC CC    Additive 0.0012 0.0024 1.76(1.25–2.47) Additive 0.0011 0.0021 1.76 (1.25–2.48)
 Nephritis+ 1055 (94.20%) 2 (0.36%) 61 (10.89%) 497 (88.75%) 0.0012 0.0016 CC + AC vs AA 0.8300 0.83 1.24 (0.17–8.84) CC vs AC + AA 0.8531 0.8531 1.20 (0.17–8.58)
  Cohort 1 867 (94.03%) 1 (0.22%) 53 (11.5%) 407 (88.29%)           
  Cohort 2 188 (94.95%) 1 (1.01%) 8 (8.08%) 90 (90.91%)           
 Nephritis 817 (90.38%) 2 (0.44%) 83 (18.36%) 367 (81.19%)    CC vs AC + AA 0.0008 0.0025 1.83 (1.28–2.60) CC + AC vs AA 0.0007 0.0022 1.84 (1.29–2.61)
  Cohort 1 664 (89.73%) 2 (0.54%) 72 (19.46%) 296 (80%)           
  Cohort 2 153 (93.29%) 0 (0.00%) 11 (13.41%) 71 (86.59%)           
ss469415590TT>ΔGb TT ΔG/ΔG ΔG/TT TT/TT    Additive 0.0015 0.0024 1.72 (1.23–2.42) Additive 0.0015 0.0021 1.73(1.23–2.42)
 Nephritis+ 1052 (94.10%) 2 (0.36%) 62 (11.09%) 495 (88.55%) 0.0011 0.0016 BB + AB vs AA 0.4927 0.657 1.87 (0.31–11.26) 2TT vs GTT + GG 0.513 0.684 1.82 (0.30–10.94)
  Cohort 1 858 (93.46%) 4 (0.87%) 52 (11.33%) 403 (87.8%)           
  Cohort 2 188 (94.00%) 1 (1.00%) 10 (10.00%) 89 (89.00%)           
 Nephritis 811 (90.31%) 3 (0.67%) 81 (18.04%) 365 (81.29%)    BB vs AB + AA 0.0013 0.0025 1.78 (1.25–2.53) 2TT + GTT vs GG 0.0012 0.0022 1.79 (1.26–2.54)
  Cohort 1 652 (88.83%) 6 (1.63%) 70 (19.07%) 291 (79.29%)           
  Cohort 2 153 (93.29%) 0 (0.00%) 11 (13.41%) 71 (86.59%)           
  1. Data presented as n (%)
  2. SLE systemic lupus erythematosus, SNP single-nucleotide polymorphism, OR odds ratio, CI confidence interval
  3. aTrend test P values generated from 10,000 permutations
  4. bGenotypes of ΔG/ΔG, ΔG/TT, and TT/TT are also named GG, GTT, and 2TT, respectively