|
SNP
|
Risk allele frequency
|
Genotype frequency
|
P
Trend
a
|
P
FDR
|
Test for mode of inheritance unadjusted
|
Test for mode of inheritance adjusted for sex and age
|
|---|
| |
P
|
P
FDR
|
OR (95% CI)
| |
P
|
P
FDR
|
OR (95% CI)
|
|---|
|
rs8099917T > G
|
T
|
GG
|
GT
|
TT
| | |
Additive
|
0.0018
|
0.0024
|
1.73 (1.23–2.45)
|
Additive
|
0.0016
|
0.0021
|
1.75 (1.24–2.47)
|
|
Nephritis+
|
1058 (94.30%)
|
1 (0.18%)
|
62 (11.05%)
|
498 (88.77%)
|
0.001
|
0.0016
|
TT + GT vs GG
|
0.45681
|
0.657
|
2.49 (0.23–27.60)
|
TT vs GT + GG
|
0.4705
|
0.684
|
2.42 (0.22–26.82)
|
|
Cohort 1
|
868 (94.14%)
|
1 (0.22%)
|
52 (11.28%)
|
408 (88.5%)
| | | | | | | | | | |
|
Cohort 2
|
190 (95.00%)
|
0 (0.00%)
|
10 (10.00%)
|
90 (90.00%)
| | | | | | | | | | |
|
Nephritis−
|
818 (90.69%)
|
2 (0.44%)
|
80 (17.74%)
|
369 (81.82%)
| | |
TT vs GT + GG
|
0.0019
|
0.0025
|
1.76 (1.23–2.50)
|
TT + GT vs GG
|
0.0016
|
0.0022
|
1.77 (1.24–2.53)
|
|
Cohort 1
|
665 (89.86%)
|
2 (0.54%)
|
71 (19.19%)
|
297 (80.27%)
| | | | | | | | | | |
|
Cohort 2
|
153 (94.44%)
|
0 (0.00%)
|
9 (11.11%)
|
72 (88.89%)
| | | | | | | | | | |
|
rs12979860T > C
|
C
|
CC
|
CT
|
TT
| | |
Additive
|
0.0036
|
0.0036
|
1.64 (1.18–2.29)
|
Additive
|
0.0034
|
0.0034
|
1.65 (1.18–2.30)
|
|
Nephritis+
|
1053 (93.85%)
|
494 (88.06%)
|
65 (11.59%)
|
2 (0.36%)
|
0.0042
|
0.0042
|
CC + CT vs TT
|
0.4949
|
0.4949
|
1.87 (0.31–11.22)
|
CC vs CT + TT
|
0.5153
|
0.5153
|
1.81 (0.30–10.91)
|
|
Cohort 1
|
865 (93.82%)
|
405 (87.85%)
|
55 (11.93%)
|
1 (0.22%)
| | | | | | | | | | |
|
Cohort 2
|
188 (94.00%)
|
89 (89.00%)
|
10 (10.00%)
|
1 (1.00%)
| | | | | | | | | | |
|
Nephritis−
|
817 (90.38%)
|
368 (81.42%)
|
81 (17.92%)
|
3 (0.66%)
| | |
CC vs CT + TT
|
0.0034
|
0.0136
|
1.68(1.19–2.38)
|
CC + CT vs TT
|
0.0031
|
0.0123
|
1.69 (1.19–2.40)
|
|
Cohort 1
|
664 (89.73%)
|
297 (80.27%)
|
70 (18.92%)
|
3 (0.81%)
| | | | | | | | | | |
|
Cohort 2
|
153 (93.29%)
|
71 (86.59%)
|
11 (13.41%)
|
0 (0.00%)
| | | | | | | | | | |
|
rs4803217C > A
|
C
|
AA
|
AC
|
CC
| | |
Additive
|
0.0012
|
0.0024
|
1.76(1.25–2.47)
|
Additive
|
0.0011
|
0.0021
|
1.76 (1.25–2.48)
|
|
Nephritis+
|
1055 (94.20%)
|
2 (0.36%)
|
61 (10.89%)
|
497 (88.75%)
|
0.0012
|
0.0016
|
CC + AC vs AA
|
0.8300
|
0.83
|
1.24 (0.17–8.84)
|
CC vs AC + AA
|
0.8531
|
0.8531
|
1.20 (0.17–8.58)
|
|
Cohort 1
|
867 (94.03%)
|
1 (0.22%)
|
53 (11.5%)
|
407 (88.29%)
| | | | | | | | | | |
|
Cohort 2
|
188 (94.95%)
|
1 (1.01%)
|
8 (8.08%)
|
90 (90.91%)
| | | | | | | | | | |
|
Nephritis−
|
817 (90.38%)
|
2 (0.44%)
|
83 (18.36%)
|
367 (81.19%)
| | |
CC vs AC + AA
|
0.0008
|
0.0025
|
1.83 (1.28–2.60)
|
CC + AC vs AA
|
0.0007
|
0.0022
|
1.84 (1.29–2.61)
|
|
Cohort 1
|
664 (89.73%)
|
2 (0.54%)
|
72 (19.46%)
|
296 (80%)
| | | | | | | | | | |
|
Cohort 2
|
153 (93.29%)
|
0 (0.00%)
|
11 (13.41%)
|
71 (86.59%)
| | | | | | | | | | |
|
ss469415590TT>ΔGb
|
TT
|
ΔG/ΔG
|
ΔG/TT
|
TT/TT
| | |
Additive
|
0.0015
|
0.0024
|
1.72 (1.23–2.42)
|
Additive
|
0.0015
|
0.0021
|
1.73(1.23–2.42)
|
|
Nephritis+
|
1052 (94.10%)
|
2 (0.36%)
|
62 (11.09%)
|
495 (88.55%)
|
0.0011
|
0.0016
|
BB + AB vs AA
|
0.4927
|
0.657
|
1.87 (0.31–11.26)
|
2TT vs GTT + GG
|
0.513
|
0.684
|
1.82 (0.30–10.94)
|
|
Cohort 1
|
858 (93.46%)
|
4 (0.87%)
|
52 (11.33%)
|
403 (87.8%)
| | | | | | | | | | |
|
Cohort 2
|
188 (94.00%)
|
1 (1.00%)
|
10 (10.00%)
|
89 (89.00%)
| | | | | | | | | | |
|
Nephritis−
|
811 (90.31%)
|
3 (0.67%)
|
81 (18.04%)
|
365 (81.29%)
| | |
BB vs AB + AA
|
0.0013
|
0.0025
|
1.78 (1.25–2.53)
|
2TT + GTT vs GG
|
0.0012
|
0.0022
|
1.79 (1.26–2.54)
|
|
Cohort 1
|
652 (88.83%)
|
6 (1.63%)
|
70 (19.07%)
|
291 (79.29%)
| | | | | | | | | | |
|
Cohort 2
|
153 (93.29%)
|
0 (0.00%)
|
11 (13.41%)
|
71 (86.59%)
| | | | | | | | | | |
- Data presented as n (%)
- SLE systemic lupus erythematosus, SNP single-nucleotide polymorphism, OR odds ratio, CI confidence interval
- aTrend test P values generated from 10,000 permutations
- bGenotypes of ΔG/ΔG, ΔG/TT, and TT/TT are also named GG, GTT, and 2TT, respectively
