Interferon-λ3/4 genetic variants and interferon-λ3 serum levels are biomarkers of lupus nephritis and disease activity in Taiwanese

Table 4 Association of IFN3/4 locus SNP haplotypes (rs8099917-ss469415590-rs12979860-rs4803217) with lupus nephritis among SLE patients

Haplotype	Estimated frequency (%)			Permutation	Logistic regression		Logistic regression adjusted for sex and age
	Nephritis⁺	Nephritis⁻	SLE cases	P*	P	OR (95% CI)	P	OR (95% CI)
	(N = 461)	(N = 370)	(N = 831)	P*	P	OR (95% CI)	P	OR (95% CI)
T-TT-C-C	91.74	86.99	89.62	0.0024	0.0018	1.66 (1.21–2.28)	0.0015	1.68 (1.22–2.32)
G-ΔG-T-A	4.44	8.23	6.13	0.0019	0.0016	0.52 (0.34–0.78)	0.0011	0.5 (0.33–0.76)
Others	3.83	4.78	4.25		0.3472	0.79 (0.49–1.28)	0.3690	0.8 (0.49–1.3)

Data presented as n (%)
*The p-values for the estimated haplotype were generated from 10,000 permutations using the EM algorithm
SLE systemic lupus erythematosus, SNP single-nucleotide polymorphism, OR odds ratio, CI confidence interval

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