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Table 4 Association of IFN3/4 locus SNP haplotypes (rs8099917-ss469415590-rs12979860-rs4803217) with lupus nephritis among SLE patients

From: Interferon-λ3/4 genetic variants and interferon-λ3 serum levels are biomarkers of lupus nephritis and disease activity in Taiwanese

Haplotype Estimated frequency (%) Permutation Logistic regression Logistic regression adjusted for sex and age
Nephritis+ Nephritis SLE cases P* P OR (95% CI) P OR (95% CI)
(N = 461) (N = 370) (N = 831)
T-TT-C-C 91.74 86.99 89.62 0.0024 0.0018 1.66 (1.21–2.28) 0.0015 1.68 (1.22–2.32)
G-ΔG-T-A 4.44 8.23 6.13 0.0019 0.0016 0.52 (0.34–0.78) 0.0011 0.5 (0.33–0.76)
Others 3.83 4.78 4.25   0.3472 0.79 (0.49–1.28) 0.3690 0.8 (0.49–1.3)
  1. Data presented as n (%)
  2. *The p-values for the estimated haplotype were generated from 10,000 permutations using the EM algorithm
  3. SLE systemic lupus erythematosus, SNP single-nucleotide polymorphism, OR odds ratio, CI confidence interval