Fig. 11From: Tofacitinib inhibits granulocyte–macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophilsNLR family pyrin domain-containing 3 (NLRP3) expression in neutrophils. Neutrophils were stimulated with granulocyte–macrophage colony-stimulating factor (GM-CSF) in the presence or absence of the indicated concentrations of tofacitinib for 24 h. Cellular lysates were analyzed by Western blot using anti-NLRP3 or anti-β-actin antibodies. Three experiments were performed by using different neutrophils, and a representative result is shownBack to article page