High-frequency ultrasound of the skin in systemic sclerosis: an exploratory study to examine correlation with disease activity and to define the minimally detectable difference

Table 2 Clinical profiles of patients with SSc with TST higher and lower than the cutoff in ROC analysis

Feature	Elevated TST (n = 24)	Normal TST (n = 7)	P
Male/female	4/20	0/7	0.247
Age (years)	50.21 ± 14.01	37.00 ± 11.02	0.187
Duration	24.00 (26.40)	56.06 ± 30.17	0.002*
DAI	5.24 ± 2.36	1.84 (1.92)	0.048*
mRSS	10.00 (6.00)	4.00 (5.00)	0.031*
RP	21	7	0.325
ILD	16	1	0.014*
PAH	5	3	0.214
DU	4	2	0.483
Muscular involvement	5	3	0.214
Synovitis	10	2	0.531
Scl-70(+)	10	3	0.955
CRP (mg/L)	8.60 (10.48)	3.52 (4.93)	0.038*
ESR (mm/h)	23.00 (16.25)	48.71 ± 43.19	0.723

SSc systemic sclerosis, TST total skin thickness, DAI European Scleroderma Trial and Research group Disease Activity Index, RP Raynaud’s phenomenon, ILD interstitial lung disease, PAH pulmonary artery hypertension, DU digital ulcers, CRP C-reactive protein, ESR erythrocyte sedimentation rate
*P < 0.05

ISSN: 1478-6362