T-cell transcriptomics from peripheral blood highlights differences between polymyositis and dermatomyositis patients

Table 1 Clinical characteristics of patients with myositis at time of blood sampling

Patient	CD4	CD8	Age (years)	Sex	Diagnosis	Autoantibodies	HLA-DRB103* status (genotype)	Prednisone	Other treatment
CEL-004	×		76	Female	PM, prob	PM-Scl	Positive (03/07)	Yes	MTX
CEL-005	×		48	Male	DM, def	SSA	Negative (11/11)	Yes	AZA, TAC
CEL-006	×		60	Male	PM, pos	SRP	Positive (03/15)	Yes	–
CEL-008	×	×	47	Male	DM, prob	MDA5	Negative (11/16)	Yes	AZA, ABT
CEL-009		×	80	Male	PM, def	Jo1	Positive (03/13)	Yes	–
CEL-010	×		74	Female	PM, prob	None	Positive (03/10)	No	IVIg
CEL-011	×	×	55	Female	DM, def	Mi-2	Negative (07/16)	Yes	MTX
CEL-014		×	74	Male	DM, def	SSA	Negative (07/11)	No	–
CEL-016	×		78	Male	DM, def	None	Positive (03/11)	Yes	MMF
CEL-017	×	×	80	Female	PM, def	None	Positive (03/13)	Yes	MTX
CEL-019	×		46	Female	DM, def	PM-Scl	Positive (03/04)	No	MTX
CEL-020	×		61	Female	PM, def	PM-Scl	Positive (01/03)	Yes	MMF
CEL-023	×		58	Male	DM, def	TIF1γ	Negative (04/07)	Yes	AZA, RIX
CEL-024	×	×	63	Female	PM, def	SSA	Positive (03/08)	Yes	AZA, CsA
CEL-027		×	65	Male	PM, def	Jo1	Positive (03/08)	Yes	–
CEL-030	×		40	Female	PM, def	Jo1	Positive (03/03)	Yes	–
CEL-031	×	×	68	Female	DM, def	TIF1γ	Negative (01/11)	Yes	–
CEL-033		×	42	Male	DM, def	MDA5	Negative (04/07)	Yes	MTX
CEL-034	×		56	Female	PM, def	Jo1, SSA, SSB	Negative (11/16)	Yes	MTX

Abbreviations: ABT Abatacept, AZA Azathioprine, CsA Cyclosporine A, Def Definite, DM Dermatomyositis, IVIg Intravenous immunoglobulin, MMF Mycophenolate mofetil, MTX Methotrexate, PM Polymyositis, Pos Possible, Prob Probable, RIX Rituximab, SRP Signal recognition particle, TAC Tacrolimus
Demographic and clinical characteristics of patients with myositis in the CD4+ (n = 15) and CD8+ T-cell subsets (n = 9) at time of blood sampling. The patients were classified according to the new European League Against Rheumatism/American College of Rheumatology classification criteria [13]

ISSN: 1478-6362