Fig. 10From: Immune complexes containing scleroderma-specific autoantibodies induce a profibrotic and proinflammatory phenotype in skin fibroblastscolIα1 and mmp-1 mRNA expression and Pro-CollagenIα1 and MMP-2 secretion in fibroblasts stimulated with SLE-ICs, PAPS-ICs or NHS-ICs. Fibroblasts exposed to PAPS-ICs, SLE-ICs or NHS-ICs (1:2 dilution). TGF-β1 (10 ng/ml) and LPS (1 μg/ml) used as positive control for collagen synthesis and secretion. a colIα1; b mmp-1; c Pro-CollagenIα1; d MMP-2. *p < 0.01, **p < 0.001, ***p < 0.0001 versus medium. colIα1 collagenIα1, IC immune complex, LPS lipopolysaccharide, MMP matrix metalloproteinase, NHS normal healthy subjects, PAPS primary anti-phospholipid syndrome, SLE systemic lupus erythematosus, TGF tumor growth factorBack to article page