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Fig. 11 | Arthritis Research & Therapy

Fig. 11

From: Immune complexes containing scleroderma-specific autoantibodies induce a profibrotic and proinflammatory phenotype in skin fibroblasts

Fig. 11

et-1, tlr2 and tlr3 expression levels in fibroblasts stimulated with SSc-ICs or NHS-ICs pretreated with DNase/RNase. SSc-ICs treated with DNase I (20 KU/ml) or RNase (8 μg/ml) and then added to fibroblast cultures. a ATA-ICs, ACA-ICs and anti-Th/To-ICs on et-1; b ATA-ICs, ACA-ICs, ARA-ICs and anti-Th/To-ICs on tlr2; c ATA-ICs and anti-Th/To-ICs on ifn-α; d ATA-ICs, ACA-ICs, ARA-ICs and anti-Th/To-ICs on tlr3. *p < 0.01, **p < 0.001, ***p < 0.0001 versus medium. ACA anti-centromeric protein antibodies, anti-Th/To anti-Th/To antibodies, ARA anti-RNA polymerase III antibodies, ATA anti-DNA topoisomerase I antibodies, et-1 endothelin-1, IC immune complex, IFN interferon, TLR Toll-like receptor

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