Fig. 1

Frequencies of circulating follicular helper T (Tfh) and follicular regulatory T (Tfr) cells in patients with rheumatoid arthritis (RA) and the healthy controls (HCs). Horizontal bars indicate the mean and error bars represent the SEM. The frequencies of circulating CD4+CXCR5+Foxp3− Tfh cells (a) and CD4+CXCR5+Foxp3+ Tfr cells (b) were investigated gating on CD4+ T cells in patients with active RA (circles), patients with inactive RA (squares), and the HCs (triangles). c Ratios of Tfh to Tfr cells in patients with active RA (circles), patients with inactive RA (squares), and the HCs (triangles)