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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: T-cell costimulation blockade is effective in experimental digestive and lung tissue fibrosis

Fig. 5

Abatacept reduces T-cell proliferation in lesional lungs of Fra-2 transgenic mice. a Representative lung sections stained by the proliferation marker Ki-67 and CD3 to quantify the number of proliferative T cells. b Abatacept (ABA) significantly reduced the number of proliferative CD3+Ki-67+ cells reported on the total number of CD3+ cells. A total of 22 mice were used (6 Fra-2 control IgG1, 8 Fra-2 abatacept 1 mg/mL, and 8 Fra-2 abatacept 10 mg/mL). Values the median ± IQR. Statistics are from post-hoc Dunnett’s multiple comparison test. **P < 0.01, ***P < 0.001

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