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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: T-cell costimulation blockade is effective in experimental digestive and lung tissue fibrosis

Fig. 6

Abatacept reduces T-cell proliferation and M1/M2 macrophage infiltration in lesional lungs of Fra-2 transgenic mice. a Representative lung sections stained for iNOS, CD11c, and F4/80 to detect type 1 (M1) macrophages, and b stained for cMAF, arginase, and F4/80 to detect type 2 (M2) macrophages. Abatacept (ABA) 1 mg/mL and 10 mg/mL significantly reduced the number of c M1 and d M2 macrophages. A total of 22 mice were used (6 Fra-2 control IgG1, 8 Fra-2 abatacept 1 mg/mL, and 8 Fra-2 abatacept 10 mg/mL). Values are the median ± IQR. Statistics are from post-hoc Dunnett’s multiple comparison test. ***P < 0.001, ****P < 0.0001

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