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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: The role of RORα in salivary gland lesions in patients with primary Sjögren’s syndrome

Fig. 3

Co-expression of RORα with CD4 and IL-17A in the labial salivary glands (LSGs). Indirect immunofluorescence analysis was used to assess RORα (green), CD4 (green) and IL-17A (red) expression and diamidino-phenyl-indole (DAPI) staining for nuclei (blue) in the LSG. Results are representative of 30 patients with primary Sjögren’s syndrome (pSS) (lower lane) and 10 normal control individuals (NC) (upper lane). The micrographs in the lower panel showed RORα-positive T helper 17 (Th17) cells in the LSGs of patients with pSS (focus score (FS) = 2), whereas the upper panel only shows some RORα-positive cells in the LSGs of NC. It indicated RORα-positive Th17 cells in the periductal tissue of LSGs of patients with pSS. Serial sections of the LSG from the same patient, and yellow arrows (lower lane) in the same direction indicated the same cell in three serial sections. Scale bars = 100 μm

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