Fig. 6
From: The role of RORα in salivary gland lesions in patients with primary Sjögren’s syndrome
Phenotypic analysis of T cells in mesenteric lymph nodes (MLNs) and cervical lymph nodes (CLNs) by flow cytometry after 4-week treatment with SR1001 or vehicle. CD4+ and IL-17+ cells in MLNs and CLNs were detected by flow cytometry after stimulation with phorbol-12-myristate-13-acetate (PMA) and ionomycin for 6 h (n = 3 for each group). CD4+ and IL-17+ double positive cells (T helper 17(Th17)) were decreased in MLNs and CLNs of non-obese diabetic (NOD) mice after 4-week SR1001treatment at both 4 weeks (4W) and 8 weeks (8W) of age (b, d) compared to vehicle groups (a, c)