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Fig. 10 | Arthritis Research & Therapy

Fig. 10

From: Osteoporosis of the vertebra and osteochondral remodeling of the endplate causes intervertebral disc degeneration in ovariectomized mice

Fig. 10

Immunohistochemical staining of vascular endothelial growth factor (VEGF). Consistent with OPN expression, a large amount of VEGF expression was observed in the outer layer of the annulus fibrosus (AF) and the bone marrow of the bony endplate (BEP) indicating that vasculogenesis and angiogenesis are associated with ossification of soft tissue and play an important role in the process of IVDD. n = 9 per group; scale bars = 20um as indicated. CEP cartilaginous endplate, EP endplate, GP growth plate, NP nucleus pulposus, VB vertebral body

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