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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Monosodium urate crystals reduce osteocyte viability and indirectly promote a shift in osteocyte function towards a proinflammatory and proresorptive state

Fig. 6

Histological analysis of human joint tissue affected by tophaceous gout. a,b Representative photomicrographs of joint samples affected by tophaceous gout, showing both MSU crystals (indicated by asterisks) and associated inflammatory tissue in close proximity to bone (a, toluidine blue staining viewed using light microscopy; b, viewed using polarizing light microscopy with a red compensator). Immunohistochemistry staining for c CD68+ cells (macrophages) and d COX-2 expression in human joint tissue affected by tophaceous gout

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