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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: 1,25(OH)2D3 and dexamethasone additively suppress synovial fibroblast activation by CCR6+ T helper memory cells and enhance the effect of tumor necrosis factor alpha blockade

Fig. 1

1,25(OH)2D3 and DEX additively suppress proinflammatory cytokines secreted by CCR6+ memTh cells. CCR6+ memTh cells were sorted from healthy individuals and cultured for 3 days under stimulation with anti-CD3 and anti-CD28, with or without 100 nM 1,25(OH)2D3 and 1000 nM dexamethasone (DEX). a Representative flow cytometry plots of interleukin (IL)-17A-, IL-22-, and interferon (IFN)γ-producing cells. b Quantification of flow cytometry as in a for six donors. c Cytokine production in the culture medium as measured by ELISA. Data show mean ± SEM for n = 6–10 healthy individuals, representative of at least three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. TNF tumor necrosis factor

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Arthritis Research & Therapy

ISSN: 1478-6362

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