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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: 1,25(OH)2D3 and dexamethasone additively suppress synovial fibroblast activation by CCR6+ T helper memory cells and enhance the effect of tumor necrosis factor alpha blockade

Fig. 4

Suppression of RASF activation by TNFα blockade is enhanced by adding DEX and 1,25(OH)2D3. CCR6+ memTh-RASF cocultures as described in Fig. 2 were exposed to 10 nM dexamethasone (DEX), 0.1 or 10 nM 1,25(OH)2D3, and 0, 0.1, 1 or 10 μg/ml etanercept or combinations of the compounds as indicated. After 3 days, synovial fibroblast activation was measured through cytokine detection using ELISA. Arrows indicate increasing concentrations. Heatmaps are constructed using the mean inhibition in each condition of n = 6 healthy donors cultured on RASF from two different RA patients. IL interleukin, MMP matrix metalloprotease

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Arthritis Research & Therapy

ISSN: 1478-6362

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