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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: 1,25(OH)2D3 and dexamethasone additively suppress synovial fibroblast activation by CCR6+ T helper memory cells and enhance the effect of tumor necrosis factor alpha blockade

Fig. 5

Additive effects of dexamethasone (DEX) and 1,25(OH)2D3 on the inhibition of RASF activation by TNFα blockade are verified for treatment-naive RA patients. Cocultures were set up as described in Fig. 4 using RASF from established RA patients and allogeneic CCR6+ memTh cells sorted from PBMCs of treatment-naive early RA patients. Cytokine expression was measured using ELISA after 3 days of culture. Arrows indicate increasing concentrations and heatmaps represent the mean inhibition per condition for n = 2–4 treatment-naive early RA patients. IL interleukin, MMP matrix metalloprotease

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Arthritis Research & Therapy

ISSN: 1478-6362

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