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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Interaction between CD177 and platelet endothelial cell adhesion molecule-1 downregulates membrane-bound proteinase-3 (PR3) expression on neutrophils and attenuates neutrophil activation induced by PR3-ANCA

Fig. 3

PECAM-1 incubation decreased antineutrophil cytoplasmic antibody (ANCA)-induced degranulation of neutrophils. Lactoferrin is considered as a biomarker of neutrophil degranulation and was detected after proteinase-3 (PR3)-ANCA immunoglobulin (Ig)G incubation for 1 h. Neutrophils treated with phorbol myristate acetate (PMA) were employed as positive control. Bars denote means ± SD of lactoferrin concentration (ng/ml). *p < 0.05. JAM-1 junctional adhesion molecule-1, PECAM-1 platelet endothelial cell adhesion molecule-1, PR3 ANCA PR3-ANCA-positive IgGs, TNF-α tumor necrosis factor-alpha

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Arthritis Research & Therapy

ISSN: 1478-6362

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