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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Interaction between CD177 and platelet endothelial cell adhesion molecule-1 downregulates membrane-bound proteinase-3 (PR3) expression on neutrophils and attenuates neutrophil activation induced by PR3-ANCA

Fig. 5

Platelet endothelial cell adhesion molecule-1 (PECAM-1) interaction with CD177 decreased GEnC activation and injury induced by patient-derived proteinase-3 (PR3)-antineutrophil cytoplasmic antibody (ANCA)-positive immunoglobulin (Ig)Gs (PR3 ANCA). By preincubation with PECAM-1, the levels of soluble intercellular cell adhesion molecule-1 (sICAM-1) significantly decreased in the supernatants of GEnCs treated with neutrophil plus patient-derived PR3-ANCA-positive IgGs. Bars denote means ± SD of sICAM-1 concentration (pg/mL). *p < 0.05. JAM-1 junctional adhesion molecule-1, PMA phorbol myristate acetate, TNF-α tumor necrosis factor-alpha

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Arthritis Research & Therapy

ISSN: 1478-6362

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