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Table 1 Clinical, serological, and immunological features of the patient cohort at baseline and after treatment with glucocorticoids

From: Increase of circulating memory B cells after glucocorticoid-induced remission identifies patients at risk of IgG4-related disease relapse

  Patients with IgG4-RD before GC (n = 30) Healthy control subjects (n = 20) p Value Patients with IgG4-RD after GC (n = 30) p Value
Definite IgG4-RD, n (%) 29 (97%)     
Probable IgG4-RD, n (%) 1 (3%)     
Possible IgG4-RD, n (%) 0 (0%)     
Age, yr, median 70 (58–73) 54 (46–65) 0.005   
Male sex, n (%) 23 (77%) 12 (60%)    
ESR (0–20 mm/h) 18 (10–35)     
CRP (< 6 mg/L) 5 (2–6)     
IgG4-RD RI (0–3) 6 (6–9)    2 (1–2.25) 0.0001
Serum IgG4 (< 135 mg/dl) 313 (206–507)    191 (87–230) 0.0001
CD19+ B cells (cells/ml) 162,000 (105,750–217,750) 236,000 (200,000–299,000) 0.0002 163,500 (100,750–233,500) 0.131
CD20+ B cells (cells/ml) 144,500 (93,000–201,700) 224,000 (199,000–279,000) 0.0001 150,500 (85,500–226,250) 0.1
Naive B cells (cells/ml) 15,120 (8895–29,140) 23,810 (17,930–54,020) 0.01 7485 (4195–14,018) 0.0001
Percentage of CD19+ B cells 10.55 (7.94–15.49) 13.02 (7.89–19.39) 0.35 4.78 (3.14–8.33) 0.0001
Memory B cells (cells/ml) 26,475 (13,040–55,450) 37,170 (21,900–57,190) 0.25 41,800 (21,148–69,435) 0.026
Percentage of CD19+ B cells 18.5 (9.26–27.31) 16.60 (9.18–26.34) 0.62 22.89 (11.14–32.50) 0.028
Plasmablasts (cells/ml) 2515 (1023–5550) 340 (170–600) 0.0001 270 (210–1198) 0.0001
Percentage of CD19+ B cells 1.25 (0.6–4.51) 0.19 (0.05–0.29) 0.0001 0.23 (0.1–0.79) 0.0001
Plasma cells (cells/ml)a 278 (0–1332) 0 (0–0) 0.0005 55 (0–423) 0.0006
Percentage of CD19+ B cellsa 0.23 (0–1.27) 0 (0–0) 0.0001 0.07 (0–0.64) 0.0008
Organ involvement, n (%)
 Pancreas 20 (66%)     
 Aorta and retroperitoneum 7 (23.3%)     
 Lymph nodes 5 (16.6%)     
 Biliary tree 5 (16.6%)     
 Salivary glands 2 (6.6%)     
 Lacrimal glands 2 (6.6%)     
 Lung 2 (6.6%)     
 Orbit 1 (3.3%)     
 Nasal sinuses 1 (3.3%)     
 Meninges 1 (3%)     
 Kidney 1 (3.3%)     
  1. Abbreviations: CRP C-reactive protein, ESR Erythrocyte sedimentation rate, IgG4-RD RI IgG4-related disease responder index, GC Glucocorticoids
  2. Results are expressed as median (IQR), except where indicated otherwise
  3. a Results expressed as mean (range)