Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: a new potential target for antifibrotic therapy

Table 1 Clinical and demographic features of the 20 patients with diffuse systemic sclerosis

Sex/age (yr)	Disease duration at skin biopsy (yr from RP)	mRSS/score at skin biopsy	Autoantibodies	ILD	PAH	SRC	RP	DU
95% F	50% EOS 50% LSS		100% ANA/Scl70	25% ILD	15% PAH;	0% SCR	100% RP	30% DU
F/45	< 1	10/2	ANA/Scl-70	No	No	No	Yes	No
F/22	< 1	13/1	ANA/Scl-70	No	No	No	Yes	Yes
F/31	< 1	08/2	ANA/Scl-70	No	No	No	Yes	No
F/38	< 1	09/2	ANA/Scl-70	No	Yes	No	Yes	Yes
M/20	< 1	11/1	ANA/Scl-70	No	No	No	Yes	No
F/40	< 1	10/2	ANA/Scl-70	No	No	No	Yes	No
F/31	< 1	10/1	ANA/Scl-70	No	No	No	Yes	No
F/21	< 1	09/1	ANA/Scl-70	No	No	No	Yes	No
F/31	< 1	14/1	ANA/Scl-70	No	No	No	Yes	No
F/42	< 1	16/2	ANA/Scl-70	Yes	No	No	Yes	No
F/45	4	17/2	ANA/Scl-70	No	No	No	Yes	No
F/21	5	15/1	ANA/Scl-70	No	No	No	Yes	No
F/30	6	18/2	ANA/Scl-70	No	Yes	No	Yes	Yes
F/33	4	13/2	ANA/Scl-70	Yes	No	No	Yes	No
F/34	4	12/1	ANA/Scl-70	No	No	No	Yes	Yes
F/40	4	10/2	ANA/Scl-70	Yes	Yes	No	Yes	No
M/26	6	10/2	ANA/Scl-70	Yes	No	No	Yes	Yes
F/21	4	11/1	ANA/Scl-70	No	No	No	Yes	No
F/30	3	12/2	ANA/Scl-70	Yes	No	No	Yes	Yes
F/33	4	12/1	ANA/Scl-70	No	No	No	Yes	No

Abbreviations: EOS Early-onset subset, LSS Long-standing subset, RP Raynaud’s phenomenon, mRSS Modified Rodnan skin score (maximum possible score 51), ILD Interstitial lung disease, ANA Antinuclear antibodies, Scl-70 Antitopoisomerase, PAH Pulmonary arterial hypertension, SRC Scleroderma renal crisis, DU Digital ulcers
The internal organ involvement is referred to the time of biopsies

ISSN: 1478-6362