Fig. 1

Knee joint swelling in SCID mice after transfer of fibroblast-like synoviocytes (FLSs). FLSs from healthy C57BL/6 mice (normal FLSs, n = 5), from C57BL/6 mice with acute AIA (7 days, acute arthritic FLSs, n = 7), or from those with chronic AIA (21 days, chronic arthritic FLSs, n = 11) were transferred into the right knee joint cavity of SCID mice. Buffer was injected as a control (control, PBS, n = 6). Joint swelling was evaluated by differences between joint diameter of right knee (ispilateral) and left knee (contralateral) at day of measurement. All data shown are mean ± standard error of mean. (* p < 0.05 vs. PBS, ** p < 0.01 vs. PBS, § p < 0.05 vs. normal FLSs; Mann-Whitney U test.) Data shown are a representative example of at least two independent experiments per group