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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Induction of chronic destructive arthritis in SCID mice by arthritogenic fibroblast-like synoviocytes derived from mice with antigen-induced arthritis

Fig. 3

Semiquantitative histologic scoring of inflammation, joint destruction, and total arthritis score in knee joint sections from SCID mice 70–100 days after transfer of FLSs. FLSs were isolated from non-immunized, non-arthritic mice (normal, n = 9), mice with acute arthritis (up to day 7 post AIA induction, n = 13), or mice with chronic AIA (isolated after day 7 post AIA induction, n = 52). Data are pooled from at least two experiments. Histological scoring was performed by two independent investigators on a 0–3 point scale for synovial lining layer hyperplasia, cellular infiltration, pannus formation, and cartilage invasion, giving a total score of 12. All data shown are mean ± standard error of mean (** p < 0.001 acute vs. normal, §§ p < 0.001 acute vs. chronic, + p < 0.01, ++ p < 0.001 chronic vs. normal, Mann-Whitney U test)

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