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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: CYLD suppression enhances the pro-inflammatory effects and hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes by enhancing NF-κB activation

Fig. 5

Effects of CYLD on cell proliferation, apoptosis, and cell cycle in RA-FLSs. We transfected RA-FLSs with sh-CYLD or sh-GFP. (A) CCK-8 test showed increased RA-FLSs proliferation in the sh-CYLD transfection group compared with the sh-GFP transfection group. (B) FCM analysis demonstrating the effect of CYLD suppression on cell apoptosis. (C) FCM analysis demonstrating the effect of CYLD suppression on cell cycle progression. Data are represented as mean ± SD from 3 independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001

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