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Table 3 Least-squares means (95% CI) of responses in patients with fibromyalgia, according to genotype
| Position | Genotype | Numbera | Tender point number | Tender point count | FIQ | BFI | PCS | MCS | BDI | STAI-I | STAI-II |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs2883187 | C/C | 100 | 13.38 (12.21–14.56) | 25.17 (21.2–29.14) | 58.56 (53.23–63.9) | 7.25 (5.28–9.22) | 38.02 (35.88–40.16) | 31.25 (27.83–34.67) | 18.09 (15.05–21.12) | 51.56 (48.06–55.06) | 51.97 (48.73–55.21) |
| C/T | 208 | 13.80 (12.83–14.77) | 25.70 (22.43–28.96) | 610 (56.69–65.32) | 6.27 (4.66–7.89) | 37.29 (35.56–39.03) | 32.62 (29.85–35.39) | 18.57 (16.11–21.02) | 49.73 (46.9–52.56) | 50.2 (47.59–52.81) | |
| T/T | 101 | 13.77 (12.54–15.0) | 25.85 (21.68–30.03) | 58.21 (52.66–63.77) | 7.16 (5.11–9.22) | 38.17 (35.94–40.41) | 34.26 (30.69–37.83) | 16.89 (13.7–20.08) | 49.49 (45.82–53.15) | 48.29 (44.9–51.68) | |
| p value† | 0.739 | 0.947 | 0.449 | 0.466 | 0.625 | 0.299 | 0.54 | 0.478 | 0.138 | ||
| rs7103873 | G/G | 98 | 13.37 (12.18–14.55) | 25.01 (21.01–29.01) | 57.96 (52.56–63.35) | 7.34 (5.35–9.32) | 37.96 (35.8–40.12) | 31.39 (27.93–34.85) | 17.78 (14.71–20.85) | 51.52 (47.98–55.06) | 51.9 (48.63–55.18) |
| G/C | 208 | 13.84 (12.88–14.81) | 25.97 (22.73–29.21) | 60.89 (56.60–65.19) | 6.25 (4.65–7.85) | 37.34 (35.62–39.07) | 32.83 (30.07–35.6) | 18.45 (16.01–20.9) | 49.51 (46.7–52.32) | 50.08 (47.48–52.68) | |
| C/C | 102 | 13.66 (12.42–14.9) | 25.28 (21.08–29.49) | 59.04 (53.43–64.64) | 7.26 (5.19–9.33) | 38.07 (35.82–40.32) | 33.52 (29.92–37.13) | 17.4 (14.18–20.62) | 50.33 (46.64–54.02) | 48.72 (45.31–52.13) | |
| p valueb | 0.69 | 0.857 | 0.479 | 0.389 | 0.721 | 0.523 | 0.755 | 0.484 | 0.224 | ||
| rs7103411 | C/C | 128 | 13.79 (12.68–14.9) | 25.97 (22.21–29.72) | 60.26 (55.22–65.3) | 6.97 (5.11–8.83) | 37.76 (35.73–39.79) | 32.88 (29.64–36.12) | 18.25 (15.37–21.14) | 50.48 (47.17–53.8) | 49.28 (46.21–52.35) |
| C/T | 198 | 13.74 (12.74–14.74) | 25.65 (22.27–29.02) | 60.54 (56.09–64.99) | 6.07 (4.41–7.73) | 37.5 (35.71–39.29) | 33.0 (30.14–35.87) | 18.32 (15.78–20.85) | 49.55 (46.62–52.47) | 50.44 (47.74–53.15) | |
| T/T | 83 | 13.46 (12.23–14.68) | 25.0 (20.87–29.14) | 57.81 (52.24–63.38) | 7.64 (5.59–9.68) | 37.79 (35.55–40.02) | 31.41 (27.84–34.98) | 17.5 (14.33–20.67) | 50.89 (47.22–54.55) | 51.09 (47.69–54.48) | |
| p valueb | 0.859 | 0.907 | 0.582 | 0.249 | 0.947 | 0.635 | 0.86 | 0.705 | 0.578 | ||
| rs10835210 | C/C | 196 | 13.49 (12.50–14.47) | 25.67 (22.37–28.97) | 59.70 (55.30–64.10) | 6.91 (5.27–8.55) | 37.78 (36.02–39.55) | 31.77 (28.96–34.58) | 18.87 (16.37–21.36) | 51.04 (48.18–53.9) | 51.77 (49.13–54.41) |
| C/A | 172 | 13.87 (12.84–14.91) | 25.51 (22.04–28.99) | 60.15 (55.46–64.85) | 6.66 (4.93–8.4) | 37.3 (35.41–39.18) | 33.19 (30.18–36.2) | 17.17 (14.5–19.83) | 48.42 (45.35–51.48) | 48.63 (45.81–51.45) | |
| A/A | 40 | 13.96 (12.18–15.74) | 24.85 (18.87–30.83) | 59.67 (51.64–67.7) | 5.46 (2.52–8.4) | 38.45 (35.22–41.67) | 35.31 (30.17–40.45) | 17.78 (13.17–22.4) | 51.79 (46.49–57.08) | 47.51 (42.62–52.4) | |
| p valueb | 0.675 | 0.962 | 0.977 | 0.609 | 0.728 | 0.301 | 0.384 | 0.138 | 0.029 | ||
| rs11030104 | A/A | 126 | 13.80 (12.68–14.92) | 25.99 (22.22–29.75) | 60.27 (55.2–65.35) | 7.0 (5.13–8.87) | 37.82 (35.77–39.86) | 32.86 (29.6–36.12) | 18.33 (15.43–21.23) | 50.46 (47.13–53.79) | 49.29 (46.2–52.37) |
| A/G | 196 | 13.79 (12.79–14.8) | 25.67 (22.3–29.03) | 60.66 (56.19–65.13) | 6.09 (4.42–7.76) | 37.4 (35.60–39.20) | 32.9 (30.02–35.77) | 18.41 (15.87–20.95) | 49.69 (46.76–52.61) | 50.53 (47.82–53.24) | |
| G/G | 85 | 13.31 (12.08–14.53) | 24.75 (20.64–28.86) | 57.55 (51.98–63.12) | 7.58 (5.53–9.62) | 37.86 (35.63–40.1) | 31.6 (28.03–35.16) | 17.31 (14.15–20.47) | 50.63 (46.99–54.28) | 50.88 (47.49–54.27) | |
| p valueb | 0.677 | 0.845 | 0.498 | 0.274 | 0.871 | 0.731 | 0.757 | 0.821 | 0.616 | ||
| rs12273539 | C/C | 268 | 13.63 (12.7–14.55) | 25.24 (22.11–28.37) | 59.03 (54.81–63.25) | 6.51 (4.95–8.07) | 37.67 (35.98–39.37) | 33.14 (30.42–35.86) | 17.45 (15.05–19.85) | 49.9 (47.14–52.66) | 49.52 (46.96–52.09) |
| C/T | 125 | 14.13 (13.01–15.24) | 27.04 (23.26–30.81) | 62.11 (57.15–67.08) | 6.75 (4.89–8.61) | 37.48 (35.48–39.47) | 31.56 (28.36–34.76) | 19.34 (16.5–22.18) | 50.66 (47.4–53.92) | 51.73 (48.7–54.75) | |
| T/T | 17 | 11.90 (9.7–14.1) | 21.96 (14.52–29.41) | 57.64 (47.31–67.96) | 8.92 (5.15–12.69) | 38.13 (33.98–42.27) | 31.82 (25.17–38.48) | 20.22 (14.35–26.09) | 49.54 (42.8–56.29) | 50.87 (44.61–57.14) | |
| p valueb | 0.131 | 0.319 | 0.349 | 0.432 | 0.945 | 0.533 | 0.26 | 0.862 | 0.271 | ||
| rs11030102 | C/C | 402 | 13.67 (12.8–14.55) | 25.57 (22.61–28.53) | 59.83 (55.89–63.77) | 6.62 (5.17–8.07) | 37.66 (36.07–39.25) | 32.67 (30.14–35.21) | 18.06 (15.83–20.29) | 50.02 (47.45–52.59) | 50.16 (47.78–52.55) |
| C/G | 6 | 17.58 (13.01–22.15) | 36.13 (20.73–51.54) | 72.91 (51.53–94.29) | 19.07 (11.35–26.79) | 35.01 (26.4–43.63) | 23.8 (10.04–37.56) | 29.58 (17.47–41.69) | 65.06 (51.13–78.99) | 62.56 (49.62–75.51) | |
| p valueb | 0.089 | 0.172 | 0.224 | 0.001 | 0.542 | 0.2 | 0.059 | 0.032 | 0.057 | ||
| rs11030101 | A/A | 197 | 13.49 (12.51–14.47) | 25.69 (22.38–29.01) | 59.82 (55.43–64.22) | 6.91 (5.27–8.55) | 37.79 (36.02–39.55) | 31.73 (28.92–34.54) | 18.94 (16.45–21.43) | 51.01 (48.15–53.87) | 51.77 (49.13–54.42) |
| A/T | 172 | 13.84 (12.81–14.87) | 25.38 (21.9–28.87) | 60.26 (55.57–64.95) | 6.69 (4.95–8.43) | 37.34 (35.45–39.22) | 33.14 (30.14–36.15) | 17.1 (14.43–19.76) | 48.41 (45.34–51.48) | 48.57 (45.75–51.4) | |
| T/T | 39 | 14.23 (12.45–16.01) | 26.37 (20.36–32.37) | 58.75 (50.73–66.77) | 5.33 (2.39–8.27) | 38.16 (34.93–41.39) | 35.94 (30.8–41.08) | 17.66 (13.12–22.21) | 52.15 (46.94–57.37) | 48.07 (43.25–52.89) | |
| p valueb | 0.605 | 0.943 | 0.929 | 0.555 | 0.816 | 0.212 | 0.325 | 0.126 | 0.033 | ||
| rs6265 | G/G | 87 | 13.29 (12.07–14.51) | 24.66 (20.55–28.78) | 57.67 (52.14–63.21) | 7.55 (5.52–9.59) | 37.83 (35.61–40.06) | 31.56 (28.01–35.11) | 17.44 (14.29–20.59) | 50.62 (46.97–54.26) | 50.94 (47.56–54.32) |
| G/A | 197 | 13.77 (12.77–14.77) | 25.62 (22.26–28.99) | 60.72 (56.27–65.18) | 6.11 (4.44–7.77) | 37.45 (35.65–39.24) | 32.92 (30.05–35.79) | 18.27 (15.74–20.81) | 49.6 (46.67–52.52) | 50.43 (47.71–53.14) | |
| A/A | 124 | 13.88 (12.76–15) | 26.34 (22.56–30.13) | 60.17 (55.09–65.24) | 6.98 (5.11–8.86) | 37.83 (35.79–39.88) | 32.91 (29.64–36.18) | 18.37 (15.47–21.28) | 50.58 (47.24–53.91) | 49.37 (46.28–52.46) | |
| p valueb | 0.634 | 0.746 | 0.513 | 0.293 | 0.898 | 0.702 | 0.829 | 0.766 | 0.657 | ||
| rs7124442 | C/T | 47 | 13.57 (12.12–15.03) | 26.18 (21.3–31.07) | 62.15 (55.49–68.81) | 5.60 (3.16–8.05) | 37.37 (34.69–40.05) | 30.74 (26.46–35.03) | 19.98 (16.2–23.76) | 50.67 (46.27–55.07) | 51.35 (47.3–55.39) |
| T/T | 360 | 13.72 (12.81–14.62) | 25.53 (22.48–28.57) | 59.53 (55.49–63.57) | 6.88 (5.37–8.39) | 37.69 (36.06–39.32) | 32.94 (30.34–35.54) | 17.81 (15.51–20.1) | 50.01 (47.36–52.66) | 50.04 (47.58–52.5) | |
| p valueb | 0.836 | 0.777 | 0.411 | 0.274 | 0.804 | 0.285 | 0.23 | 0.755 | 0.501 |
