Table 3 Least-squares means (95% CI) of responses in patients with fibromyalgia, according to genotype

rs2883187

C/C

13.38 (12.21–14.56)

25.17 (21.2–29.14)

58.56 (53.23–63.9)

7.25 (5.28–9.22)

38.02 (35.88–40.16)

31.25 (27.83–34.67)

18.09 (15.05–21.12)

51.56 (48.06–55.06)

51.97 (48.73–55.21)

C/T

13.80 (12.83–14.77)

25.70 (22.43–28.96)

610 (56.69–65.32)

6.27 (4.66–7.89)

37.29 (35.56–39.03)

32.62 (29.85–35.39)

18.57 (16.11–21.02)

49.73 (46.9–52.56)

50.2 (47.59–52.81)

T/T

13.77 (12.54–15.0)

25.85 (21.68–30.03)

58.21 (52.66–63.77)

7.16 (5.11–9.22)

38.17 (35.94–40.41)

34.26 (30.69–37.83)

16.89 (13.7–20.08)

49.49 (45.82–53.15)

48.29 (44.9–51.68)

p value^†

0.739

0.947

0.449

0.466

0.625

0.299

0.54

0.478

0.138

rs7103873

G/G

13.37 (12.18–14.55)

25.01 (21.01–29.01)

57.96 (52.56–63.35)

7.34 (5.35–9.32)

37.96 (35.8–40.12)

31.39 (27.93–34.85)

17.78 (14.71–20.85)

51.52 (47.98–55.06)

51.9 (48.63–55.18)

G/C

13.84 (12.88–14.81)

25.97 (22.73–29.21)

60.89 (56.60–65.19)

6.25 (4.65–7.85)

37.34 (35.62–39.07)

32.83 (30.07–35.6)

18.45 (16.01–20.9)

49.51 (46.7–52.32)

50.08 (47.48–52.68)

C/C

13.66 (12.42–14.9)

25.28 (21.08–29.49)

59.04 (53.43–64.64)

7.26 (5.19–9.33)

38.07 (35.82–40.32)

33.52 (29.92–37.13)

17.4 (14.18–20.62)

50.33 (46.64–54.02)

48.72 (45.31–52.13)

p value^b

0.69

0.857

0.479

0.389

0.721

0.523

0.755

0.484

0.224

rs7103411

C/C

13.79 (12.68–14.9)

25.97 (22.21–29.72)

60.26 (55.22–65.3)

6.97 (5.11–8.83)

37.76 (35.73–39.79)

32.88 (29.64–36.12)

18.25 (15.37–21.14)

50.48 (47.17–53.8)

49.28 (46.21–52.35)

C/T

13.74 (12.74–14.74)

25.65 (22.27–29.02)

60.54 (56.09–64.99)

6.07 (4.41–7.73)

37.5 (35.71–39.29)

33.0 (30.14–35.87)

18.32 (15.78–20.85)

49.55 (46.62–52.47)

50.44 (47.74–53.15)

T/T

13.46 (12.23–14.68)

25.0 (20.87–29.14)

57.81 (52.24–63.38)

7.64 (5.59–9.68)

37.79 (35.55–40.02)

31.41 (27.84–34.98)

17.5 (14.33–20.67)

50.89 (47.22–54.55)

51.09 (47.69–54.48)

p value^b

0.859

0.907

0.582

0.249

0.947

0.635

0.86

0.705

0.578

rs10835210

C/C

13.49 (12.50–14.47)

25.67 (22.37–28.97)

59.70 (55.30–64.10)

6.91 (5.27–8.55)

37.78 (36.02–39.55)

31.77 (28.96–34.58)

18.87 (16.37–21.36)

51.04 (48.18–53.9)

51.77 (49.13–54.41)

C/A

13.87 (12.84–14.91)

25.51 (22.04–28.99)

60.15 (55.46–64.85)

6.66 (4.93–8.4)

37.3 (35.41–39.18)

33.19 (30.18–36.2)

17.17 (14.5–19.83)

48.42 (45.35–51.48)

48.63 (45.81–51.45)

A/A

13.96 (12.18–15.74)

24.85 (18.87–30.83)

59.67 (51.64–67.7)

5.46 (2.52–8.4)

38.45 (35.22–41.67)

35.31 (30.17–40.45)

17.78 (13.17–22.4)

51.79 (46.49–57.08)

47.51 (42.62–52.4)

p value^b

0.675

0.962

0.977

0.609

0.728

0.301

0.384

0.138

0.029

rs11030104

A/A

13.80 (12.68–14.92)

25.99 (22.22–29.75)

60.27 (55.2–65.35)

7.0 (5.13–8.87)

37.82 (35.77–39.86)

32.86 (29.6–36.12)

18.33 (15.43–21.23)

50.46 (47.13–53.79)

49.29 (46.2–52.37)

A/G

13.79 (12.79–14.8)

25.67 (22.3–29.03)

60.66 (56.19–65.13)

6.09 (4.42–7.76)

37.4 (35.60–39.20)

32.9 (30.02–35.77)

18.41 (15.87–20.95)

49.69 (46.76–52.61)

50.53 (47.82–53.24)

G/G

13.31 (12.08–14.53)

24.75 (20.64–28.86)

57.55 (51.98–63.12)

7.58 (5.53–9.62)

37.86 (35.63–40.1)

31.6 (28.03–35.16)

17.31 (14.15–20.47)

50.63 (46.99–54.28)

50.88 (47.49–54.27)

p value^b

0.677

0.845

0.498

0.274

0.871

0.731

0.757

0.821

0.616

rs12273539

C/C

13.63 (12.7–14.55)

25.24 (22.11–28.37)

59.03 (54.81–63.25)

6.51 (4.95–8.07)

37.67 (35.98–39.37)

33.14 (30.42–35.86)

17.45 (15.05–19.85)

49.9 (47.14–52.66)

49.52 (46.96–52.09)

C/T

14.13 (13.01–15.24)

27.04 (23.26–30.81)

62.11 (57.15–67.08)

6.75 (4.89–8.61)

37.48 (35.48–39.47)

31.56 (28.36–34.76)

19.34 (16.5–22.18)

50.66 (47.4–53.92)

51.73 (48.7–54.75)

T/T

11.90 (9.7–14.1)

21.96 (14.52–29.41)

57.64 (47.31–67.96)

8.92 (5.15–12.69)

38.13 (33.98–42.27)

31.82 (25.17–38.48)

20.22 (14.35–26.09)

49.54 (42.8–56.29)

50.87 (44.61–57.14)

p value^b

0.131

0.319

0.349

0.432

0.945

0.533

0.26

0.862

0.271

rs11030102

C/C

13.67 (12.8–14.55)

25.57 (22.61–28.53)

59.83 (55.89–63.77)

6.62 (5.17–8.07)

37.66 (36.07–39.25)

32.67 (30.14–35.21)

18.06 (15.83–20.29)

50.02 (47.45–52.59)

50.16 (47.78–52.55)

C/G

17.58 (13.01–22.15)

36.13 (20.73–51.54)

72.91 (51.53–94.29)

19.07 (11.35–26.79)

35.01 (26.4–43.63)

23.8 (10.04–37.56)

29.58 (17.47–41.69)

65.06 (51.13–78.99)

62.56 (49.62–75.51)

p value^b

0.089

0.172

0.224

0.001

0.542

0.2

0.059

0.032

0.057

rs11030101

A/A

13.49 (12.51–14.47)

25.69 (22.38–29.01)

59.82 (55.43–64.22)

6.91 (5.27–8.55)

37.79 (36.02–39.55)

31.73 (28.92–34.54)

18.94 (16.45–21.43)

51.01 (48.15–53.87)

51.77 (49.13–54.42)

A/T

13.84 (12.81–14.87)

25.38 (21.9–28.87)

60.26 (55.57–64.95)

6.69 (4.95–8.43)

37.34 (35.45–39.22)

33.14 (30.14–36.15)

17.1 (14.43–19.76)

48.41 (45.34–51.48)

48.57 (45.75–51.4)

T/T

14.23 (12.45–16.01)

26.37 (20.36–32.37)

58.75 (50.73–66.77)

5.33 (2.39–8.27)

38.16 (34.93–41.39)

35.94 (30.8–41.08)

17.66 (13.12–22.21)

52.15 (46.94–57.37)

48.07 (43.25–52.89)

p value^b

0.605

0.943

0.929

0.555

0.816

0.212

0.325

0.126

0.033

rs6265

G/G

13.29 (12.07–14.51)

24.66 (20.55–28.78)

57.67 (52.14–63.21)

7.55 (5.52–9.59)

37.83 (35.61–40.06)

31.56 (28.01–35.11)

17.44 (14.29–20.59)

50.62 (46.97–54.26)

50.94 (47.56–54.32)

G/A

13.77 (12.77–14.77)

25.62 (22.26–28.99)

60.72 (56.27–65.18)

6.11 (4.44–7.77)

37.45 (35.65–39.24)

32.92 (30.05–35.79)

18.27 (15.74–20.81)

49.6 (46.67–52.52)

50.43 (47.71–53.14)

A/A

13.88 (12.76–15)

26.34 (22.56–30.13)

60.17 (55.09–65.24)

6.98 (5.11–8.86)

37.83 (35.79–39.88)

32.91 (29.64–36.18)

18.37 (15.47–21.28)

50.58 (47.24–53.91)

49.37 (46.28–52.46)

p value^b

0.634

0.746

0.513

0.293

0.898

0.702

0.829

0.766

0.657

rs7124442

C/T

13.57 (12.12–15.03)

26.18 (21.3–31.07)

62.15 (55.49–68.81)

5.60 (3.16–8.05)

37.37 (34.69–40.05)

30.74 (26.46–35.03)

19.98 (16.2–23.76)

50.67 (46.27–55.07)

51.35 (47.3–55.39)

T/T

13.72 (12.81–14.62)

25.53 (22.48–28.57)

59.53 (55.49–63.57)

6.88 (5.37–8.39)

37.69 (36.06–39.32)

32.94 (30.34–35.54)

17.81 (15.51–20.1)

50.01 (47.36–52.66)

50.04 (47.58–52.5)

p value^b

0.836

0.777

0.411

0.274

0.804

0.285

0.23

0.755

0.501