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Table 3 Least-squares means (95% CI) of responses in patients with fibromyalgia, according to genotype

From: Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study

Position Genotype Numbera Tender point number Tender point count FIQ BFI PCS MCS BDI STAI-I STAI-II
rs2883187 C/C 100 13.38 (12.21–14.56) 25.17 (21.2–29.14) 58.56 (53.23–63.9) 7.25 (5.28–9.22) 38.02 (35.88–40.16) 31.25 (27.83–34.67) 18.09 (15.05–21.12) 51.56 (48.06–55.06) 51.97 (48.73–55.21)
  C/T 208 13.80 (12.83–14.77) 25.70 (22.43–28.96) 610 (56.69–65.32) 6.27 (4.66–7.89) 37.29 (35.56–39.03) 32.62 (29.85–35.39) 18.57 (16.11–21.02) 49.73 (46.9–52.56) 50.2 (47.59–52.81)
  T/T 101 13.77 (12.54–15.0) 25.85 (21.68–30.03) 58.21 (52.66–63.77) 7.16 (5.11–9.22) 38.17 (35.94–40.41) 34.26 (30.69–37.83) 16.89 (13.7–20.08) 49.49 (45.82–53.15) 48.29 (44.9–51.68)
p value    0.739 0.947 0.449 0.466 0.625 0.299 0.54 0.478 0.138
rs7103873 G/G 98 13.37 (12.18–14.55) 25.01 (21.01–29.01) 57.96 (52.56–63.35) 7.34 (5.35–9.32) 37.96 (35.8–40.12) 31.39 (27.93–34.85) 17.78 (14.71–20.85) 51.52 (47.98–55.06) 51.9 (48.63–55.18)
  G/C 208 13.84 (12.88–14.81) 25.97 (22.73–29.21) 60.89 (56.60–65.19) 6.25 (4.65–7.85) 37.34 (35.62–39.07) 32.83 (30.07–35.6) 18.45 (16.01–20.9) 49.51 (46.7–52.32) 50.08 (47.48–52.68)
  C/C 102 13.66 (12.42–14.9) 25.28 (21.08–29.49) 59.04 (53.43–64.64) 7.26 (5.19–9.33) 38.07 (35.82–40.32) 33.52 (29.92–37.13) 17.4 (14.18–20.62) 50.33 (46.64–54.02) 48.72 (45.31–52.13)
p valueb    0.69 0.857 0.479 0.389 0.721 0.523 0.755 0.484 0.224
rs7103411 C/C 128 13.79 (12.68–14.9) 25.97 (22.21–29.72) 60.26 (55.22–65.3) 6.97 (5.11–8.83) 37.76 (35.73–39.79) 32.88 (29.64–36.12) 18.25 (15.37–21.14) 50.48 (47.17–53.8) 49.28 (46.21–52.35)
  C/T 198 13.74 (12.74–14.74) 25.65 (22.27–29.02) 60.54 (56.09–64.99) 6.07 (4.41–7.73) 37.5 (35.71–39.29) 33.0 (30.14–35.87) 18.32 (15.78–20.85) 49.55 (46.62–52.47) 50.44 (47.74–53.15)
  T/T 83 13.46 (12.23–14.68) 25.0 (20.87–29.14) 57.81 (52.24–63.38) 7.64 (5.59–9.68) 37.79 (35.55–40.02) 31.41 (27.84–34.98) 17.5 (14.33–20.67) 50.89 (47.22–54.55) 51.09 (47.69–54.48)
p valueb    0.859 0.907 0.582 0.249 0.947 0.635 0.86 0.705 0.578
rs10835210 C/C 196 13.49 (12.50–14.47) 25.67 (22.37–28.97) 59.70 (55.30–64.10) 6.91 (5.27–8.55) 37.78 (36.02–39.55) 31.77 (28.96–34.58) 18.87 (16.37–21.36) 51.04 (48.18–53.9) 51.77 (49.13–54.41)
  C/A 172 13.87 (12.84–14.91) 25.51 (22.04–28.99) 60.15 (55.46–64.85) 6.66 (4.93–8.4) 37.3 (35.41–39.18) 33.19 (30.18–36.2) 17.17 (14.5–19.83) 48.42 (45.35–51.48) 48.63 (45.81–51.45)
  A/A 40 13.96 (12.18–15.74) 24.85 (18.87–30.83) 59.67 (51.64–67.7) 5.46 (2.52–8.4) 38.45 (35.22–41.67) 35.31 (30.17–40.45) 17.78 (13.17–22.4) 51.79 (46.49–57.08) 47.51 (42.62–52.4)
p valueb    0.675 0.962 0.977 0.609 0.728 0.301 0.384 0.138 0.029
rs11030104 A/A 126 13.80 (12.68–14.92) 25.99 (22.22–29.75) 60.27 (55.2–65.35) 7.0 (5.13–8.87) 37.82 (35.77–39.86) 32.86 (29.6–36.12) 18.33 (15.43–21.23) 50.46 (47.13–53.79) 49.29 (46.2–52.37)
  A/G 196 13.79 (12.79–14.8) 25.67 (22.3–29.03) 60.66 (56.19–65.13) 6.09 (4.42–7.76) 37.4 (35.60–39.20) 32.9 (30.02–35.77) 18.41 (15.87–20.95) 49.69 (46.76–52.61) 50.53 (47.82–53.24)
  G/G 85 13.31 (12.08–14.53) 24.75 (20.64–28.86) 57.55 (51.98–63.12) 7.58 (5.53–9.62) 37.86 (35.63–40.1) 31.6 (28.03–35.16) 17.31 (14.15–20.47) 50.63 (46.99–54.28) 50.88 (47.49–54.27)
p valueb    0.677 0.845 0.498 0.274 0.871 0.731 0.757 0.821 0.616
rs12273539 C/C 268 13.63 (12.7–14.55) 25.24 (22.11–28.37) 59.03 (54.81–63.25) 6.51 (4.95–8.07) 37.67 (35.98–39.37) 33.14 (30.42–35.86) 17.45 (15.05–19.85) 49.9 (47.14–52.66) 49.52 (46.96–52.09)
  C/T 125 14.13 (13.01–15.24) 27.04 (23.26–30.81) 62.11 (57.15–67.08) 6.75 (4.89–8.61) 37.48 (35.48–39.47) 31.56 (28.36–34.76) 19.34 (16.5–22.18) 50.66 (47.4–53.92) 51.73 (48.7–54.75)
  T/T 17 11.90 (9.7–14.1) 21.96 (14.52–29.41) 57.64 (47.31–67.96) 8.92 (5.15–12.69) 38.13 (33.98–42.27) 31.82 (25.17–38.48) 20.22 (14.35–26.09) 49.54 (42.8–56.29) 50.87 (44.61–57.14)
p valueb    0.131 0.319 0.349 0.432 0.945 0.533 0.26 0.862 0.271
rs11030102 C/C 402 13.67 (12.8–14.55) 25.57 (22.61–28.53) 59.83 (55.89–63.77) 6.62 (5.17–8.07) 37.66 (36.07–39.25) 32.67 (30.14–35.21) 18.06 (15.83–20.29) 50.02 (47.45–52.59) 50.16 (47.78–52.55)
  C/G 6 17.58 (13.01–22.15) 36.13 (20.73–51.54) 72.91 (51.53–94.29) 19.07 (11.35–26.79) 35.01 (26.4–43.63) 23.8 (10.04–37.56) 29.58 (17.47–41.69) 65.06 (51.13–78.99) 62.56 (49.62–75.51)
p valueb    0.089 0.172 0.224 0.001 0.542 0.2 0.059 0.032 0.057
rs11030101 A/A 197 13.49 (12.51–14.47) 25.69 (22.38–29.01) 59.82 (55.43–64.22) 6.91 (5.27–8.55) 37.79 (36.02–39.55) 31.73 (28.92–34.54) 18.94 (16.45–21.43) 51.01 (48.15–53.87) 51.77 (49.13–54.42)
  A/T 172 13.84 (12.81–14.87) 25.38 (21.9–28.87) 60.26 (55.57–64.95) 6.69 (4.95–8.43) 37.34 (35.45–39.22) 33.14 (30.14–36.15) 17.1 (14.43–19.76) 48.41 (45.34–51.48) 48.57 (45.75–51.4)
  T/T 39 14.23 (12.45–16.01) 26.37 (20.36–32.37) 58.75 (50.73–66.77) 5.33 (2.39–8.27) 38.16 (34.93–41.39) 35.94 (30.8–41.08) 17.66 (13.12–22.21) 52.15 (46.94–57.37) 48.07 (43.25–52.89)
p valueb    0.605 0.943 0.929 0.555 0.816 0.212 0.325 0.126 0.033
rs6265 G/G 87 13.29 (12.07–14.51) 24.66 (20.55–28.78) 57.67 (52.14–63.21) 7.55 (5.52–9.59) 37.83 (35.61–40.06) 31.56 (28.01–35.11) 17.44 (14.29–20.59) 50.62 (46.97–54.26) 50.94 (47.56–54.32)
  G/A 197 13.77 (12.77–14.77) 25.62 (22.26–28.99) 60.72 (56.27–65.18) 6.11 (4.44–7.77) 37.45 (35.65–39.24) 32.92 (30.05–35.79) 18.27 (15.74–20.81) 49.6 (46.67–52.52) 50.43 (47.71–53.14)
  A/A 124 13.88 (12.76–15) 26.34 (22.56–30.13) 60.17 (55.09–65.24) 6.98 (5.11–8.86) 37.83 (35.79–39.88) 32.91 (29.64–36.18) 18.37 (15.47–21.28) 50.58 (47.24–53.91) 49.37 (46.28–52.46)
p valueb    0.634 0.746 0.513 0.293 0.898 0.702 0.829 0.766 0.657
rs7124442 C/T 47 13.57 (12.12–15.03) 26.18 (21.3–31.07) 62.15 (55.49–68.81) 5.60 (3.16–8.05) 37.37 (34.69–40.05) 30.74 (26.46–35.03) 19.98 (16.2–23.76) 50.67 (46.27–55.07) 51.35 (47.3–55.39)
  T/T 360 13.72 (12.81–14.62) 25.53 (22.48–28.57) 59.53 (55.49–63.57) 6.88 (5.37–8.39) 37.69 (36.06–39.32) 32.94 (30.34–35.54) 17.81 (15.51–20.1) 50.01 (47.36–52.66) 50.04 (47.58–52.5)
p valueb    0.836 0.777 0.411 0.274 0.804 0.285 0.23 0.755 0.501
  1. Abbreviations: CI confidence interval, FIQ Fibromyalgia Impact Questionnaire, BFI Brief Fatigue Inventory, PCS Physical Component Summary, MCS Mental Component Summary, BDI Beck Depression Inventory, STAI-I State-Trait Anxiety Inventory-I, STAI-II State-Trait Anxiety Inventory-II
  2. aMissing data were excluded from the analyses: BDNF rs2883187 (5 controls), BDNF rs7103873 (1 patient and 16 controls), BDNF rs7103411 (2 controls), BDNF rs10835210 (1 patient and 10 controls), BDNF rs11030104 (2 patients and 3 controls), BDNF rs12273539 (1 control), BDNF rs11030102 (1 patient and 1 control), BDNF rs11030101 (1 patient and 3 controls), BDNF rs6265 (4 controls and 1 patient), and BDNF rs7124442 (2 patients and 2 controls)
  3. bp values derived by analysis of covariance adjusted for age and sex