|
Position
|
Genotype
|
Numbera
|
Tender point number
|
Tender point count
|
FIQ
|
BFI
|
PCS
|
MCS
|
BDI
|
STAI-I
|
STAI-II
|
|---|
|
rs2883187
|
C/C
|
100
|
13.38 (12.21–14.56)
|
25.17 (21.2–29.14)
|
58.56 (53.23–63.9)
|
7.25 (5.28–9.22)
|
38.02 (35.88–40.16)
|
31.25 (27.83–34.67)
|
18.09 (15.05–21.12)
|
51.56 (48.06–55.06)
|
51.97 (48.73–55.21)
|
| |
C/T
|
208
|
13.80 (12.83–14.77)
|
25.70 (22.43–28.96)
|
610 (56.69–65.32)
|
6.27 (4.66–7.89)
|
37.29 (35.56–39.03)
|
32.62 (29.85–35.39)
|
18.57 (16.11–21.02)
|
49.73 (46.9–52.56)
|
50.2 (47.59–52.81)
|
| |
T/T
|
101
|
13.77 (12.54–15.0)
|
25.85 (21.68–30.03)
|
58.21 (52.66–63.77)
|
7.16 (5.11–9.22)
|
38.17 (35.94–40.41)
|
34.26 (30.69–37.83)
|
16.89 (13.7–20.08)
|
49.49 (45.82–53.15)
|
48.29 (44.9–51.68)
|
|
p value†
| | |
0.739
|
0.947
|
0.449
|
0.466
|
0.625
|
0.299
|
0.54
|
0.478
|
0.138
|
|
rs7103873
|
G/G
|
98
|
13.37 (12.18–14.55)
|
25.01 (21.01–29.01)
|
57.96 (52.56–63.35)
|
7.34 (5.35–9.32)
|
37.96 (35.8–40.12)
|
31.39 (27.93–34.85)
|
17.78 (14.71–20.85)
|
51.52 (47.98–55.06)
|
51.9 (48.63–55.18)
|
| |
G/C
|
208
|
13.84 (12.88–14.81)
|
25.97 (22.73–29.21)
|
60.89 (56.60–65.19)
|
6.25 (4.65–7.85)
|
37.34 (35.62–39.07)
|
32.83 (30.07–35.6)
|
18.45 (16.01–20.9)
|
49.51 (46.7–52.32)
|
50.08 (47.48–52.68)
|
| |
C/C
|
102
|
13.66 (12.42–14.9)
|
25.28 (21.08–29.49)
|
59.04 (53.43–64.64)
|
7.26 (5.19–9.33)
|
38.07 (35.82–40.32)
|
33.52 (29.92–37.13)
|
17.4 (14.18–20.62)
|
50.33 (46.64–54.02)
|
48.72 (45.31–52.13)
|
|
p valueb
| | |
0.69
|
0.857
|
0.479
|
0.389
|
0.721
|
0.523
|
0.755
|
0.484
|
0.224
|
|
rs7103411
|
C/C
|
128
|
13.79 (12.68–14.9)
|
25.97 (22.21–29.72)
|
60.26 (55.22–65.3)
|
6.97 (5.11–8.83)
|
37.76 (35.73–39.79)
|
32.88 (29.64–36.12)
|
18.25 (15.37–21.14)
|
50.48 (47.17–53.8)
|
49.28 (46.21–52.35)
|
| |
C/T
|
198
|
13.74 (12.74–14.74)
|
25.65 (22.27–29.02)
|
60.54 (56.09–64.99)
|
6.07 (4.41–7.73)
|
37.5 (35.71–39.29)
|
33.0 (30.14–35.87)
|
18.32 (15.78–20.85)
|
49.55 (46.62–52.47)
|
50.44 (47.74–53.15)
|
| |
T/T
|
83
|
13.46 (12.23–14.68)
|
25.0 (20.87–29.14)
|
57.81 (52.24–63.38)
|
7.64 (5.59–9.68)
|
37.79 (35.55–40.02)
|
31.41 (27.84–34.98)
|
17.5 (14.33–20.67)
|
50.89 (47.22–54.55)
|
51.09 (47.69–54.48)
|
|
p valueb
| | |
0.859
|
0.907
|
0.582
|
0.249
|
0.947
|
0.635
|
0.86
|
0.705
|
0.578
|
|
rs10835210
|
C/C
|
196
|
13.49 (12.50–14.47)
|
25.67 (22.37–28.97)
|
59.70 (55.30–64.10)
|
6.91 (5.27–8.55)
|
37.78 (36.02–39.55)
|
31.77 (28.96–34.58)
|
18.87 (16.37–21.36)
|
51.04 (48.18–53.9)
|
51.77 (49.13–54.41)
|
| |
C/A
|
172
|
13.87 (12.84–14.91)
|
25.51 (22.04–28.99)
|
60.15 (55.46–64.85)
|
6.66 (4.93–8.4)
|
37.3 (35.41–39.18)
|
33.19 (30.18–36.2)
|
17.17 (14.5–19.83)
|
48.42 (45.35–51.48)
|
48.63 (45.81–51.45)
|
| |
A/A
|
40
|
13.96 (12.18–15.74)
|
24.85 (18.87–30.83)
|
59.67 (51.64–67.7)
|
5.46 (2.52–8.4)
|
38.45 (35.22–41.67)
|
35.31 (30.17–40.45)
|
17.78 (13.17–22.4)
|
51.79 (46.49–57.08)
|
47.51 (42.62–52.4)
|
|
p valueb
| | |
0.675
|
0.962
|
0.977
|
0.609
|
0.728
|
0.301
|
0.384
|
0.138
|
0.029
|
|
rs11030104
|
A/A
|
126
|
13.80 (12.68–14.92)
|
25.99 (22.22–29.75)
|
60.27 (55.2–65.35)
|
7.0 (5.13–8.87)
|
37.82 (35.77–39.86)
|
32.86 (29.6–36.12)
|
18.33 (15.43–21.23)
|
50.46 (47.13–53.79)
|
49.29 (46.2–52.37)
|
| |
A/G
|
196
|
13.79 (12.79–14.8)
|
25.67 (22.3–29.03)
|
60.66 (56.19–65.13)
|
6.09 (4.42–7.76)
|
37.4 (35.60–39.20)
|
32.9 (30.02–35.77)
|
18.41 (15.87–20.95)
|
49.69 (46.76–52.61)
|
50.53 (47.82–53.24)
|
| |
G/G
|
85
|
13.31 (12.08–14.53)
|
24.75 (20.64–28.86)
|
57.55 (51.98–63.12)
|
7.58 (5.53–9.62)
|
37.86 (35.63–40.1)
|
31.6 (28.03–35.16)
|
17.31 (14.15–20.47)
|
50.63 (46.99–54.28)
|
50.88 (47.49–54.27)
|
|
p valueb
| | |
0.677
|
0.845
|
0.498
|
0.274
|
0.871
|
0.731
|
0.757
|
0.821
|
0.616
|
|
rs12273539
|
C/C
|
268
|
13.63 (12.7–14.55)
|
25.24 (22.11–28.37)
|
59.03 (54.81–63.25)
|
6.51 (4.95–8.07)
|
37.67 (35.98–39.37)
|
33.14 (30.42–35.86)
|
17.45 (15.05–19.85)
|
49.9 (47.14–52.66)
|
49.52 (46.96–52.09)
|
| |
C/T
|
125
|
14.13 (13.01–15.24)
|
27.04 (23.26–30.81)
|
62.11 (57.15–67.08)
|
6.75 (4.89–8.61)
|
37.48 (35.48–39.47)
|
31.56 (28.36–34.76)
|
19.34 (16.5–22.18)
|
50.66 (47.4–53.92)
|
51.73 (48.7–54.75)
|
| |
T/T
|
17
|
11.90 (9.7–14.1)
|
21.96 (14.52–29.41)
|
57.64 (47.31–67.96)
|
8.92 (5.15–12.69)
|
38.13 (33.98–42.27)
|
31.82 (25.17–38.48)
|
20.22 (14.35–26.09)
|
49.54 (42.8–56.29)
|
50.87 (44.61–57.14)
|
|
p valueb
| | |
0.131
|
0.319
|
0.349
|
0.432
|
0.945
|
0.533
|
0.26
|
0.862
|
0.271
|
|
rs11030102
|
C/C
|
402
|
13.67 (12.8–14.55)
|
25.57 (22.61–28.53)
|
59.83 (55.89–63.77)
|
6.62 (5.17–8.07)
|
37.66 (36.07–39.25)
|
32.67 (30.14–35.21)
|
18.06 (15.83–20.29)
|
50.02 (47.45–52.59)
|
50.16 (47.78–52.55)
|
| |
C/G
|
6
|
17.58 (13.01–22.15)
|
36.13 (20.73–51.54)
|
72.91 (51.53–94.29)
|
19.07 (11.35–26.79)
|
35.01 (26.4–43.63)
|
23.8 (10.04–37.56)
|
29.58 (17.47–41.69)
|
65.06 (51.13–78.99)
|
62.56 (49.62–75.51)
|
|
p valueb
| | |
0.089
|
0.172
|
0.224
|
0.001
|
0.542
|
0.2
|
0.059
|
0.032
|
0.057
|
|
rs11030101
|
A/A
|
197
|
13.49 (12.51–14.47)
|
25.69 (22.38–29.01)
|
59.82 (55.43–64.22)
|
6.91 (5.27–8.55)
|
37.79 (36.02–39.55)
|
31.73 (28.92–34.54)
|
18.94 (16.45–21.43)
|
51.01 (48.15–53.87)
|
51.77 (49.13–54.42)
|
| |
A/T
|
172
|
13.84 (12.81–14.87)
|
25.38 (21.9–28.87)
|
60.26 (55.57–64.95)
|
6.69 (4.95–8.43)
|
37.34 (35.45–39.22)
|
33.14 (30.14–36.15)
|
17.1 (14.43–19.76)
|
48.41 (45.34–51.48)
|
48.57 (45.75–51.4)
|
| |
T/T
|
39
|
14.23 (12.45–16.01)
|
26.37 (20.36–32.37)
|
58.75 (50.73–66.77)
|
5.33 (2.39–8.27)
|
38.16 (34.93–41.39)
|
35.94 (30.8–41.08)
|
17.66 (13.12–22.21)
|
52.15 (46.94–57.37)
|
48.07 (43.25–52.89)
|
|
p valueb
| | |
0.605
|
0.943
|
0.929
|
0.555
|
0.816
|
0.212
|
0.325
|
0.126
|
0.033
|
|
rs6265
|
G/G
|
87
|
13.29 (12.07–14.51)
|
24.66 (20.55–28.78)
|
57.67 (52.14–63.21)
|
7.55 (5.52–9.59)
|
37.83 (35.61–40.06)
|
31.56 (28.01–35.11)
|
17.44 (14.29–20.59)
|
50.62 (46.97–54.26)
|
50.94 (47.56–54.32)
|
| |
G/A
|
197
|
13.77 (12.77–14.77)
|
25.62 (22.26–28.99)
|
60.72 (56.27–65.18)
|
6.11 (4.44–7.77)
|
37.45 (35.65–39.24)
|
32.92 (30.05–35.79)
|
18.27 (15.74–20.81)
|
49.6 (46.67–52.52)
|
50.43 (47.71–53.14)
|
| |
A/A
|
124
|
13.88 (12.76–15)
|
26.34 (22.56–30.13)
|
60.17 (55.09–65.24)
|
6.98 (5.11–8.86)
|
37.83 (35.79–39.88)
|
32.91 (29.64–36.18)
|
18.37 (15.47–21.28)
|
50.58 (47.24–53.91)
|
49.37 (46.28–52.46)
|
|
p valueb
| | |
0.634
|
0.746
|
0.513
|
0.293
|
0.898
|
0.702
|
0.829
|
0.766
|
0.657
|
|
rs7124442
|
C/T
|
47
|
13.57 (12.12–15.03)
|
26.18 (21.3–31.07)
|
62.15 (55.49–68.81)
|
5.60 (3.16–8.05)
|
37.37 (34.69–40.05)
|
30.74 (26.46–35.03)
|
19.98 (16.2–23.76)
|
50.67 (46.27–55.07)
|
51.35 (47.3–55.39)
|
| |
T/T
|
360
|
13.72 (12.81–14.62)
|
25.53 (22.48–28.57)
|
59.53 (55.49–63.57)
|
6.88 (5.37–8.39)
|
37.69 (36.06–39.32)
|
32.94 (30.34–35.54)
|
17.81 (15.51–20.1)
|
50.01 (47.36–52.66)
|
50.04 (47.58–52.5)
|
|
p valueb
| | |
0.836
|
0.777
|
0.411
|
0.274
|
0.804
|
0.285
|
0.23
|
0.755
|
0.501
|
- Abbreviations: CI confidence interval, FIQ Fibromyalgia Impact Questionnaire, BFI Brief Fatigue Inventory, PCS Physical Component Summary, MCS Mental Component Summary, BDI Beck Depression Inventory, STAI-I State-Trait Anxiety Inventory-I, STAI-II State-Trait Anxiety Inventory-II
- aMissing data were excluded from the analyses: BDNF rs2883187 (5 controls), BDNF rs7103873 (1 patient and 16 controls), BDNF rs7103411 (2 controls), BDNF rs10835210 (1 patient and 10 controls), BDNF rs11030104 (2 patients and 3 controls), BDNF rs12273539 (1 control), BDNF rs11030102 (1 patient and 1 control), BDNF rs11030101 (1 patient and 3 controls), BDNF rs6265 (4 controls and 1 patient), and BDNF rs7124442 (2 patients and 2 controls)
- bp values derived by analysis of covariance adjusted for age and sex
