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Table 2 Site-specific association with increase in MRI-detected OPs over 2.6 years

From: MRI-detected osteophytes of the knee: natural history and structural correlates of change

  Multivariable* Multivariable**
RR (95% CI) RR (95% CI)
Increase in MRI-detected OPs (yes or no)
 Medial BMLs 1.37 (1.19, 1.58) 1.17 (1.02, 1.35)
 Lateral BMLs 1.81 (1.11, 2.97) 1.11 (0.84, 2.40)
 Patellar BMLs 1.16 (1.02, 1.33) 1.14 (0.94, 1.37)
 Total BMLs 1.30 (1.19, 1.42) 1.16 (1.03, 1.31)
 Medial cartilage defects 1.39 (1.25, 1.54) 1.30 (1.16, 1.45)
 Lateral cartilage defects 1.42 (1.26, 1.61) 1.35 (1.21, 1.51)
 Patellar cartilage defects 1.34 (1.22, 1.47) 1.25 (1.13, 1.38)
 Total cartilage defects 2.19 (1.71, 2.80) 1.33 (1.20, 1.46)
 Medial meniscal extrusion 1.39 (1.12, 1.71) 1.24 (1.00, 1.55)
 Lateral meniscal extrusion 1.50 (1.27, 1.79) 1.33 (1.14, 1.56)
 Total meniscal extrusion 1.40 (1.17, 1.69) 1.22 (1.01, 1.47)
  1. Dependent variable: increases in magnetic resonance imaging (MRI)-detected osteophytes (OPs) (yes or no) in the same compartment as each exposure. Independent variables: baseline bone marrow lesions (BMLs), cartilage defects, meniscal extrusion (per grade)
  2. *Adjusted for age, sex and body mass index
  3. **Further adjusted for other structural abnormalities and baseline OP scores. Bold denotes statistical significance