Relevance of interferon-gamma in pathogenesis of life-threatening rapidly progressive interstitial lung disease in patients with dermatomyositis

Table 1 Clinical characteristics of patients

	DM with RP-ILD	DM without RP-ILD	p value
n	9	10
Age, years	69.3 ± 3.9	63.9 ± 14.2	0.68
Female (n, %)	8, 88.9	6, 60.0	0.31
Disease duration (months)	18.1 ± 39.8	7.6 ± 8.7	0.40
Smokers (current and past) (%)	11.1	30.0	0.31
Number of GC pulses	2.2 ± 1.1	N/A
PaO₂/FiO₂ ratio	160 ± 90	N/A
Leukocyte count (/μL)	9438 ± 5751	7620 ± 5458	0.35
LDH (U/L)	549 ± 357	376 ± 168	0.27
KL-6 (U/mL)	1087 ± 584	1419 ± 1756	0.46
IgG (mg/dL)	1225 ± 398	1452 ± 454	0.27
Positivity for anti-CADM140/MDA5 Ab (%)	66.7	50.0	0.76
CT score (G)	2.1 ± 0.7	N/A
CT score (F)	1.2 ± 0.6	N/A

Data are mean ± SD or number of patients (percentage)
DM dermatomyositis, RP-ILD rapidly progressive-interstitial lung disease, GC glucocorticoid, PaO₂/FiO₂ partial arterial pressure of oxygen/fraction of inspired oxygen, KL-6 Kerbs von Lungren 6 antigen, CT computed tomograpghy, G ground glass opacity, F fibrosis