Skip to main content

Table 3 Comparison of mutational analysis in patients with YOFMF, AOFMF, and LOFMF (univariate analyses)

From: Musculoskeletal manifestations occur predominantly in patients with later-onset familial Mediterranean fever: Data from a multicenter, prospective national cohort study in Japan

Variable YOFMF (n = 182) AOFMF (n = 115) LOFMF (n = 90) p value
YOFMF vs AOFMF vs LOFMF YOFMF vs others Others vs LOFMF
MEFV mutations (+) 171/182 (94%) 106/115 (92%) 78/90 (87%) 0.12 0.14 0.078
Exon 1 mutations (+) 11/182 (6%) 6/115 (5%) 0/90 (0%) 0.064 0.15 0.016
Exon 2 mutations (+) 127/182 (70%) 83/115 (72%) 61/90 (68%) 0.79 1.00 0.60
Exon 3 mutations (+) 22/182 (12%) 14/115 (12%) 15/90 (17%) 0.54 0.65 0.29
Exon 10 mutations (+) 89/182 (49%) 35/115 (30%) 16/90 (18%) < 0.0001 < 0.0001 < 0.0001
Heterozygote mutations (+) 22/182 (12%) 13/115 (11%) 5/90 (6%) 0.23 0.32 0.11
More than two MEFV mutations (+) 125/182 (69%) 65/115 (57%) 41/90 (46%) 0.0009 0.0009 0.0022
  1. Number (percentage) presented. p values established using Fisher’s exact test or Mann–Whitney U test
  2. YOFMF young-onset FMF, AOFMF adult-onset FMF, LOFMF late-onset FMF, FMF familial Mediterranean fever, MEFV Mediterranean fever gene