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Table 3 Comparison of mutational analysis in patients with YOFMF, AOFMF, and LOFMF (univariate analyses)

From: Musculoskeletal manifestations occur predominantly in patients with later-onset familial Mediterranean fever: Data from a multicenter, prospective national cohort study in Japan

Variable

YOFMF (n = 182)

AOFMF (n = 115)

LOFMF (n = 90)

p value

YOFMF vs AOFMF vs LOFMF

YOFMF vs others

Others vs LOFMF

MEFV mutations (+)

171/182 (94%)

106/115 (92%)

78/90 (87%)

0.12

0.14

0.078

Exon 1 mutations (+)

11/182 (6%)

6/115 (5%)

0/90 (0%)

0.064

0.15

0.016

Exon 2 mutations (+)

127/182 (70%)

83/115 (72%)

61/90 (68%)

0.79

1.00

0.60

Exon 3 mutations (+)

22/182 (12%)

14/115 (12%)

15/90 (17%)

0.54

0.65

0.29

Exon 10 mutations (+)

89/182 (49%)

35/115 (30%)

16/90 (18%)

< 0.0001

< 0.0001

< 0.0001

Heterozygote mutations (+)

22/182 (12%)

13/115 (11%)

5/90 (6%)

0.23

0.32

0.11

More than two MEFV mutations (+)

125/182 (69%)

65/115 (57%)

41/90 (46%)

0.0009

0.0009

0.0022

  1. Number (percentage) presented. p values established using Fisher’s exact test or Mann–Whitney U test
  2. YOFMF young-onset FMF, AOFMF adult-onset FMF, LOFMF late-onset FMF, FMF familial Mediterranean fever, MEFV Mediterranean fever gene