Table 4 Characteristics of the YOFMF, AOFMF, and LOFMF patients in a sensitivity analysis removing patients with mutations in exon 10 or overlapping rheumatic diseases (univariate analyses)
Variable | YOFMF (n = 91) | AOFMF (n = 74) | LOFMF (n = 61) | p value | ||
|---|---|---|---|---|---|---|
YOFMF vs AOFMF vs LOFMF | YOFMF vs others | Others vs LOFMF | ||||
Typical FMF | 33/91 (36%) | 25/74 (34%) | 25/61 (41%) | 0.68 | 1.00 | 0.44 |
Family history | 15/91 (16%) | 9/74 (12%) | 6/61 (10%) | 0.47 | 0.32 | 0.51 |
Exon 1 mutations (+) | 11/91 (12%) | 6/74 (8%) | 0/61 (0%) | 0.021 | 0.041 | 0.0078 |
Exon 2 mutations (+) | 62/91 (68%) | 58/74 (78%) | 40/61 (66%) | 0.20 | 0.55 | 0.32 |
Exon 3 mutations (+) | 22/91 (24%) | 14/74 (19%) | 12/61 (20%) | 0.67 | 0.41 | 0.86 |
More than two MEFV mutations (+) | 48/91 (53%) | 39/74 (53%) | 24/61 (39%) | 0.20 | 0.42 | 0.10 |
Thoracic pain | 17/91 (19%) | 19/74 (26%) | 17/61 (28%) | 0.36 | 0.20 | 0.38 |
Abdominal pain | 55/91 (60%) | 34/74 (46%) | 13/61 (21%) | < 0.0001 | 0.0002 | < 0.0001 |
Arthritis | 40/91 (44%) | 39/74 (53%) | 39/61 (64%) | 0.053 | 0.043 | 0.036 |
Myalgia | 4/76 (5%) | 12/56 (21%) | 12/42 (29%) | 0.0018 | 0.0007 | 0.016 |