From: The inflammatory response in the regression of lumbar disc herniation
Immune mediator | Sample | Species | Study |
---|---|---|---|
IL-6, NO, PGE2, MMP-3, MMP-2/MMP-9 | Herniated IVD tissue | Human | Kang et al., 1997 [42] |
IL-8, MCP-1 | Herniated IVD tissue | Human | Burke et al., 2002 [37] |
IL-4, IL-6, IL-12, IFN-γ | Herniated IVD tissue | Human | Shamji et al., 2010 [32] |
MMP-3, MMP-7 | Coculture of IVD and macrophages | Mouse | Haro et al., 2000 [45] |
MMP-7, TNF-α | Coculture of IVD and macrophages | Mouse | Haro et al., 2000 [46] |
MMP-3, MMP-7, TNF-α, VEGF | Coculture of IVD and macrophages | Mouse | Kato et al., 2004 [47] |
IL-6 | Coculture of IVD and macrophages | Rat | Takada et al., 2004 [43] |
IL-8, PGE2, COX-2 | Coculture of IVD and macrophages | Rat | Takada et al., 2012 [44] |