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Table 1 Immune mediators implicating macrophages in LDH regression

From: The inflammatory response in the regression of lumbar disc herniation

Immune mediator Sample Species Study
IL-6, NO, PGE2, MMP-3, MMP-2/MMP-9 Herniated IVD tissue Human Kang et al., 1997 [42]
IL-8, MCP-1 Herniated IVD tissue Human Burke et al., 2002 [37]
IL-4, IL-6, IL-12, IFN-γ Herniated IVD tissue Human Shamji et al., 2010 [32]
MMP-3, MMP-7 Coculture of IVD and macrophages Mouse Haro et al., 2000 [45]
MMP-7, TNF-α Coculture of IVD and macrophages Mouse Haro et al., 2000 [46]
MMP-3, MMP-7, TNF-α, VEGF Coculture of IVD and macrophages Mouse Kato et al., 2004 [47]
IL-6 Coculture of IVD and macrophages Rat Takada et al., 2004 [43]
IL-8, PGE2, COX-2 Coculture of IVD and macrophages Rat Takada et al., 2012 [44]
  1. COX-2 cyclooxygenase 2, IFN-γ interferon gamma, IL interleukin, IVD intervertebral disc, LDH lumbar disc herniation, MCP-1 monocyte chemoattractant protein-1, MMP matrix metalloproteinase, NO nitric oxide, PGE2 prostaglandin E2, TNF-α tumor necrosis factor alpha, VEGF vascular endothelial growth factor
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